{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:01:42Z","timestamp":1780470102949,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:00:00Z","timestamp":1348099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute hemorrhagic edema of infancy (<jats:styled-content style=\"fixed-case\">AHEI<\/jats:styled-content>) is a cutaneous vasculitis seen in children. Many consider it to be a clinical variant of Sch\u00f6nlein\u2013Henoch purpura, but others regard it as a separate entity because of its benign nature, age of onset, lack of visceral involvement, and frequent absence of vascular immunoglobulin A deposition. It is clinically characterized by large \u201ccockade\u201d or rosette\u2010shaped, annular, purpuric lesions involving the face and extremities; erythematous edema; and mild fever. It seems to appear secondary to a history of viral or bacterial infection, course of antibiotics, or vaccination. Because of the unknown etiology and benign character, which leads to spontaneous complete recovery, there is no specific treatment necessary for <jats:styled-content style=\"fixed-case\">AHEI<\/jats:styled-content>, and according to the literature, systemic corticosteroids do not seem to alter the course of the disease. We report the case of an 11\u2010month\u2010old boy who manifested massive periorbital edema along with all of the clinical characteristics of this entity and showed clear improvement of the symptoms after a 24\u2010hour administration of systemic corticosteroid therapy. Given the positive effect of this therapy, we propose that systemic corticosteroids should be used to ameliorate the acute manifestations and avoid the rapid progression of the disease.<\/jats:p>","DOI":"10.1111\/j.1525-1470.2012.01871.x","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T03:03:13Z","timestamp":1348196593000},"source":"Crossref","is-referenced-by-count":6,"title":["Visual Impairment Caused by Periorbital Edema in an Infant with Acute Hemorrhagic Edema of Infancy"],"prefix":"10.1111","volume":"30","author":[{"given":"Priscila","family":"Freitas","sequence":"first","affiliation":[{"name":"Department of Pulmonology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Bygum","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1913.04350010020008"},{"key":"e_1_2_5_3_1","volume-title":"Lehrbuch der Sa\u00fcglings Krankheiten","author":"Finkelstein H","year":"1938"},{"key":"e_1_2_5_4_1","first-page":"283","article-title":"Acute hemorrhagic edema of infancy: Finkelstein's disease","volume":"61","author":"Long D","year":"1998","journal-title":"Cutis"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70219-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.0024d.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70338-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80202-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70002-J"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1998.tb01289.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1996.tb01186.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1995.tb00163.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01820.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199604000-00012"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21504.x"},{"key":"e_1_2_5_17_1","first-page":"127","article-title":"Infantile acute hemorrhagic edema of the skin","volume":"68","author":"Paradisi M","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03917.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00336.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2003.01796.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0667"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00253.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1525-1470.2012.01871.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1470.2012.01871.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:19:33Z","timestamp":1696033173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1525-1470.2012.01871.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,20]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/j.1525-1470.2012.01871.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1525-1470.2012.01871.x","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,20]]}}}