{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:53:05Z","timestamp":1698702785174},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical data from 120 adult patients with genetically undifferentiated polycystic kidney disease who had been followed up for more than 3 months (range 3\u2013172) were reviewed in order to try to identify clinical indicators that might predict deterioration in renal function. They were split into two groups dependent on whether annualized fall in estimated glomerular filtration rate (\u0394eGFR mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup>\/year) was statistically significant or not. Only 26 patients (22%) had a statistically significantly decreasing \u0394eGFR with a median decrease of \u22122.6\u2003mL\/min\/1.73\u2003m<jats:sup>2<\/jats:sup>\/year (range \u22126.2 to \u22120.7). There was no difference in initial age, gender, or racial distributions between the groups or in initial eGFR. Follow\u2010up was longer (median 86, range 23\u2013172 months vs. 46, range 3\u2013161 months; <jats:italic>P<\/jats:italic>\u2003=\u2003 0.002) and initial blood pressure values tended to be lower (with mean systolic values of 128 vs. 148\u2003mm\u2003Hg; <jats:italic>P<\/jats:italic>\u2003=\u20030.02) in the group with statistically significant fall in \u0394eGFR, but this trend failed to achieve an a priori level of statistical significance. However, the proportion of patients with initial systolic blood pressure \u2264144 developing a statistically significant fall in \u0394eGFR was 0.26 (95% confidence interval\u2003=\u20030.13 to 0.45). No differences were found in initial hemoglobin or cholesterol concentrations. Overall, the annualized rate of decrease in eGFR tended to be greater in those with the higher initial eGFR (<jats:italic>P<\/jats:italic>\u2003=\u20030.04), but correlation was poor (<jats:italic>rho<\/jats:italic><jats:sup>2<\/jats:sup>=\u20030.04) and failed to achieve an a priori level of statistical significance. No statistically significant correlation was found between \u0394eGFR and any other variable. Only those patients with polycystic kidney disease with a statistically significant annualized decrease in eGFR may need to be referred for hospital follow\u2010up in the renal clinic. This simple selection would reduce referrals by 78%.<\/jats:p>","DOI":"10.1111\/j.1525-1594.2012.01441.x","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T18:16:34Z","timestamp":1334772994000},"page":"594-599","source":"Crossref","is-referenced-by-count":4,"title":["Adult Polycystic Kidney Disease: Who Needs Hospital Follow\u2010Up?"],"prefix":"10.1111","volume":"36","author":[{"given":"Ioannis","family":"Griveas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"World","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.10.002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1681\/ASN.V121194","article-title":"Hypertension in autosomal\u2010dominant polycystic kidney disease: early occurrence and unique aspects","volume":"12","author":"Ecder T","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06531-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.319"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1983.51"},{"key":"e_1_2_6_7_2","first-page":"1","article-title":"Bilateral polycystic disease of the kidneys: a follow\u2010up of two hundred and eighty\u2010four patients and their families","volume":"328","author":"Dalgaard OZ","year":"1957","journal-title":"Acta Med Scand Suppl"},{"key":"e_1_2_6_8_2","first-page":"81","article-title":"Patterns of autosomal dominant polycystic kidney diseases in black Africans","volume":"21","author":"Fary Ka E","year":"2010","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_2_6_9_2","first-page":"146","article-title":"Increased prevalence of dialysis\u2010dependent renal failure in ethnic minorities in the West Midlands","volume":"8","author":"Clark TJ","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V5122037"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(85)80004-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37228-2"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.238"},{"key":"e_1_2_6_14_2","first-page":"653","article-title":"Pathogenesis of hypertension in autosomal dominant polycystic kidney disease","volume":"11","author":"Chapman AR","year":"1991","journal-title":"Semin Nephrol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.330"},{"key":"e_1_2_6_16_2","first-page":"49","article-title":"Autosomal dominant polycystic kidney disease: the renin angiotensin\u2010aldosterone system, hypertension, and left ventricular hypertrophy","volume":"10","author":"Schrier RW","year":"2004","journal-title":"Curr Med Lit-Nephrol Hypertens"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008080882"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200156"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe068078"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1525-1594.2012.01441.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1594.2012.01441.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:41:45Z","timestamp":1697406105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1525-1594.2012.01441.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,18]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1525-1594.2012.01441.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1525-1594.2012.01441.x","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,18]]}}}