{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:01:54Z","timestamp":1760472114301},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T00:00:00Z","timestamp":1352678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this clinical trial was to evaluate the pulsatile perfusion mode in pediatric patients who had complex cardiac pathologies according to Jenkins stratifications (category 4) undergoing cardiopulmonary bypass procedures (<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>). Patients with transposition of great arteries (<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>) and ventricular septal defect (<jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content>) were included in this clinical study. Eighty\u2010nine consecutive pediatric patients undergoing open heart surgery for repair of <jats:styled-content style=\"fixed-case\">TGA\u2010VSD<\/jats:styled-content> were prospectively entered into the study and were randomly assigned to either the pulsatile perfusion group (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>, <jats:italic>n<\/jats:italic>\u2009=\u200958) or the nonpulsatile perfusion group (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>, <jats:italic>n<\/jats:italic>\u2009=\u200931). There were no differences between groups in terms of demographical and intraoperative parameters. The pulsatile group needed significantly less inotropic support (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and had lower lactate levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), higher urine output (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and higher albumin levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In addition, the pulsatile group had less ICU (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and hospital stays (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). We conclude that the use of pulsatile flow is a better option and should be considered for repair of the complex congenital heart defects.<\/jats:p>","DOI":"10.1111\/j.1525-1594.2012.01552.x","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T17:38:49Z","timestamp":1352741929000},"page":"82-86","source":"Crossref","is-referenced-by-count":23,"title":["Impact of Pulsatile Perfusion on Clinical Outcomes of Neonates and Infants With Complex Pathologies Undergoing Cardiopulmonary Bypass Procedures"],"prefix":"10.1111","volume":"37","author":[{"given":"Tijen","family":"Alkan\u2010Bozkaya","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"At\u0131f","family":"Ak\u00e7evin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"T\u00fcrko\u011flu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akif","family":"\u00dcndar","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Surgery and Bioengineering Penn State Hershey College of Medicine, Pediatric Cardiovascular Research Center  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00963.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","DOI":"10.1177\/0267659112451304","article-title":"Invited commentary; Using a secondary reservoir for pump suckers to avoid the generation of foam during CPB procedures in pediatric patients","author":"\u00dcndar A","year":"2012","journal-title":"Perfusion"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182226b75"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.02.053"},{"key":"e_1_2_6_6_1","first-page":"P26","article-title":"Clinical outcomes of pulsatile and non\u2010pulsatile mode of perfusion","volume":"41","author":"Haines N","year":"2009","journal-title":"J Extracorpor Technol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2010.01159.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659111404468"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01378.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135110394218"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1051\/ject\/201244010","article-title":"A meta\u2010analysis of renal benefits to pulsatile perfusion in cardiac surgery","volume":"44","author":"Sievert A","year":"2012","journal-title":"J Extra Corpor Technol"},{"key":"e_1_2_6_12_1","first-page":"P20","article-title":"Quantification of pressure\u2010flow waveforms and selection of components for the pulsatile ECC","volume":"41","author":"Wang S","year":"2009","journal-title":"J Extracorpor Technol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00911.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00971.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2004.02.009"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1525-1594.2012.01552.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1594.2012.01552.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:40:07Z","timestamp":1697614807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1525-1594.2012.01552.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,12]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1525-1594.2012.01552.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1525-1594.2012.01552.x","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,12]]}}}