{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:30:47Z","timestamp":1762090247723,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T00:00:00Z","timestamp":1140480000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>Background.\u2014Cerebrovascular and cardiovascular complications in migraineurs may be part of the migraine process and also consequent to triptan treatment<\/jats:p>\n                  <jats:p>Aim.\u2014To determine the frequency, subtypes and associations of migraine\u2010associated stroke and angina in young people (18\u201349 years).<\/jats:p>\n                  <jats:p>Methods.\u2014Patients were derived from a tertiary referral migraine and stroke registry. Migraine\u2010associated stroke was classified according to the four groups described by Welch and by the TOAST etiological stroke classification. A clinical description of angina during a migraine attack was required for the diagnosis of cardiac migraine without concomitant triptan or other vasoactive medications<\/jats:p>\n                  <jats:p>\n                    Results.\u2014Of the young patients with stroke (349\/1316; 26.5%), there were 30 (30\/349; 8.6%) who had migraine at the time of stroke when categorized by the Welch classification type II to IV (type II n = 5, type III n = 2, type IV n = 3). Comparison of type I (n = 20) versus types II\u2013IV (n = 10) showed significant difference (\n                    <jats:italic>P<\/jats:italic>\n                    = .03). Topographically the lesions were distributed into the partial anterior circulation (n = 8) and posterior circulation (n = 2) (\n                    <jats:italic>P<\/jats:italic>\n                    = .04). Comparison of anterior and posterior circulation territories of infarction indicated significant difference (n = 26\/30 and 4\/30;\n                    <jats:italic>P<\/jats:italic>\n                    = .01). The stroke etiological subtypes included cardiogenic (n = 5), atherogenic (n = 15), other (n = 5), and unknown (n = 5), with none diagnosed with small\u2010vessel cerebrovascular disease. Traditional stroke mechanistic entities (cardiac and atherogenic) differed significantly in comparison to the other and unknown categories\n                    <jats:italic>P<\/jats:italic>\n                    = .05. Cardiovascular patients with angina during a migraine attack (n = 9\/1040; 0.9%), included IHS subtypes; migraine without aura (n = 4), migraine with aura (n = 4), and complicated migraine (n = 1). One patient required cardiac catheterization on account of significant ECG changes, with documented, reversible vasospasm.\n                  <\/jats:p>\n                  <jats:p>Conclusion.\u2014(i) Migraine\u2010induced stroke remains controversial, with only two probable cases of type Welch III A+B in a large registry. (ii) Cardiac migraine may be a distinct entity requiring careful differentiation from triptan\u2010induced chest pain.<\/jats:p>","DOI":"10.1111\/j.1526-4610.2006.00333.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T08:38:19Z","timestamp":1152693499000},"page":"208-211","source":"Crossref","is-referenced-by-count":1,"title":["Stroke and Chest Pain in Young People With Migraine"],"prefix":"10.1111","volume":"46","author":[{"given":"Michael","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,21]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199810040-00005"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050146"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.1068"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000117212"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03062_16.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03023.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70003-7"},{"key":"e_1_2_8_9_2","first-page":"1226","article-title":"Stroke in the young in South Africa\u2014an analysis of 320 patients","volume":"90","author":"Hoffmann M","year":"2000","journal-title":"SAMJ"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1997.3708519.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331977402500301"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1996.3605332.x"},{"key":"e_1_2_8_13_2","first-page":"209","article-title":"Migraine and acute myocardial infarction","volume":"8","author":"Garcia\u2010Albea E","year":"1993","journal-title":"Neurologia (Spain)"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979004100306"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1996.3605332.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2002.02173.x"},{"key":"e_1_2_8_17_2","first-page":"1","article-title":"Classification of headache disorders, cranial neuralgias and facial pain; and diagnostic criteria for primary headache disorders","volume":"8","author":"Classification Committee of the International Headache Society","year":"1988","journal-title":"Cephalalgia"},{"key":"e_1_2_8_18_2","first-page":"33","article-title":"Relationship of stroke and migraine","volume":"44","author":"Welch KMA","year":"1994","journal-title":"Neurology"},{"key":"e_1_2_8_19_2","first-page":"374","volume-title":"Wolff's Headache and Other Facial Pain","author":"Bousser MG","year":"2001"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6983.830"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7175.13"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90669-8"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90134-4"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198103263041306"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1526-4610.2006.00333.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1526-4610.2006.00333.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:25:54Z","timestamp":1762089954000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/j.1526-4610.2006.00333.x"}},"subtitle":["<b>\n                      <i>CME<\/i>\n                    <\/b>"],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1526-4610.2006.00333.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1526-4610.2006.00333.x","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"type":"print","value":"0017-8748"},{"type":"electronic","value":"1526-4610"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}