{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:00:22Z","timestamp":1787014822282,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T00:00:00Z","timestamp":1142899200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>Objective.\u2014To assess whether the biallelic \u2013231 G&gt;A polymorphism of the endothelin type A receptor (EDNRA) gene, previously shown to be a marker of increased risk for developing migraine, has a role in the susceptibility to primary pediatric headache.<\/jats:p>\n                  <jats:p>Background.\u2014Several studies suggest that endothelin has a role in migraine. A recent association study has shown that the biallelic \u2013231 G&gt;A polymorphism of the EDNRA gene is associated to migraine in an elderly population.<\/jats:p>\n                  <jats:p>Methods.\u2014A total of 126 consecutive unrelated pediatric patients affected by primary headache, classified according to the International Headache Society criteria in migraine (migraine with aura, n = 3; migraine without aura, n = 80), and tension\u2010type headache (episodic tension\u2010type headache, n = 36; chronic tension\u2010type headache, n = 7) patients, were recruited to the study. Sixty\u2010seven healthy blood donors were used as a control group. Genomic DNA was extracted from buccal swabs or blood samples and analyzed by polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) for the above\u2010mentioned polymorphism. Allele and genotype frequencies for primary headache patients were analyzed in comparison with the control group.<\/jats:p>\n                  <jats:p>\n                    Results.\u2014No significant differences were found in the distribution of the EDNRA \u2013231 G&gt;A polymorphic variant when considering both genotype (migraine \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 2.78,\n                    <jats:italic>P<\/jats:italic>\n                    = .25; tension\u2010type headache \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 3.58,\n                    <jats:italic>P<\/jats:italic>\n                    = .17) and allelic frequencies (migraine \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 1.48,\n                    <jats:italic>P<\/jats:italic>\n                    = .22; tension\u2010type headache \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 0.39,\n                    <jats:italic>P<\/jats:italic>\n                    = .56). Furthermore, no significant genotype\u2010related difference was found in relation to clinical features, such as age at onset, frequency, and length of the attacks.\n                  <\/jats:p>\n                  <jats:p>Conclusions.\u2014Our study shows that the \u2013231 G&gt;A polymorphism in the EDNRA gene is neither associated with primary juvenile headache nor significantly correlated with main clinical features characteristic of the headache pathology in pediatric settings.<\/jats:p>","DOI":"10.1111\/j.1526-4610.2006.00380.x","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T05:29:15Z","timestamp":1142918955000},"page":"486-491","source":"Crossref","is-referenced-by-count":15,"title":["Endothelin Receptor A \u2013231 G&gt;A Polymorphism: No Linkage to Primary Pediatric Headache"],"prefix":"10.1111","volume":"46","author":[{"given":"Veronica","family":"Lisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Garbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PierAntonio","family":"Battistella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Miccich\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Terrazzino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malida","family":"Franzoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Tripoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Clementi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s00439-003-1055-9","article-title":"Update on the genetics of migraine","volume":"114","author":"Estevez M","year":"2004","journal-title":"Hum Genet."},{"key":"e_1_2_7_3_2","first-page":"1","article-title":"The International Classification of Headache Disorders, 2nd edition","volume":"24","author":"Headache Classification Committee of the International Headache Society","year":"2004","journal-title":"Cephalagia."},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000026233","article-title":"The relationship of migraine and stroke","volume":"19","author":"Tietjen GE","year":"2000","journal-title":"Neuroepidemiology."},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1468-2982.2000.00003.x","article-title":"Molecular genetics of migraine headache: A review","volume":"20","author":"Montagna P","year":"2000","journal-title":"Cephalalgia."},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/348730a0","article-title":"Cloning and 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Scand."},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00001756-199902050-00039","article-title":"Simultaneous monitoring of endothelin\u20101 and vasopressin plasma levels in migraine","volume":"10","author":"Hasselblatt M","year":"1999","journal-title":"Neuroreport."},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1212\/WNL.56.10.1273","article-title":"Association between migraine and endothelin type A receptor (ETA \u2010231 A\/G) gene polymorphism","volume":"56","author":"Tzourio C","year":"2001","journal-title":"Neurology."},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1185\/0300799039117005","article-title":"Epidemiology and economic impact of migraine","volume":"17","author":"Lipton RB","year":"2001","journal-title":"Curr Med Res Opin."},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1526-4610.1977.hed1704173.x","article-title":"An epidemiologic study of migraine and headache in 10\u201320 year olds","volume":"17","author":"Deubner DC","year":"1977","journal-title":"Headache."},{"key":"e_1_2_7_14_2","first-page":"33","volume-title":"Juvenile Headache","author":"Gallai V","year":"1991"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0895-7061(98)00255-6","article-title":"Polymorphisms of the endothelin\u2010A and \u2010B receptor genes in relation to blood pressure and myocardial infarction: The Etude Cas\u2010Temoins sur l'Infarctus du Myocarde (ECTIM) Study","volume":"12","author":"Nicaud V","year":"1999","journal-title":"Am J Hypertens."},{"key":"e_1_2_7_16_2","first-page":"1187","article-title":"Association between Raynaud's phenomenon and migraine in a random population of hospital employees","volume":"20","author":"O'Keefe ST","year":"1993","journal-title":"J Rheumatol."},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2261-4-20","article-title":"A common genetic factor underlies hypertension and other cardiovascular disorders","volume":"4","author":"Williams FM","year":"2004","journal-title":"BMC Cardiovasc Disord."}],"container-title":["Headache: The Journal of Head and Face 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