{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:14:10Z","timestamp":1793261650944,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:00:00Z","timestamp":1144195200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>\n                    Background.\u2014Mechanical compression of the trigeminal root by an artery is thought to cause trigeminal neuralgia. The 5\u2010HT\n                    <jats:sub>1B\/1D<\/jats:sub>\n                    receptor agonist may inhibit neurogenic inflammation and vasodilation near the irritated trigeminal root.\n                  <\/jats:p>\n                  <jats:p>\n                    Objective.\u2014To examine the effectiveness of a 5\u2010HT\n                    <jats:sub>1B\/1D<\/jats:sub>\n                    receptor agonist, sumatriptan, on a paroxysmal pain in trigeminal neuralgia.\n                  <\/jats:p>\n                  <jats:p>Methods.\u2014Twenty\u2010four patients with trigeminal neuralgia refractory to previous treatment were randomized to receive subcutaneously either 3 mg (1 mL) of sumatriptan or 1 mL of saline placebo. Following a 7\u2010day period, patients crossed over to receive the alternative treatment. Paroxysmal pain triggered by touching or moving the face was assessed with VAS before and 15 minutes after the treatment. Patients used a descriptive scale to pain\u2010grade outcome, and asked to note whether the pain returned and how long after therapy it recurred.<\/jats:p>\n                  <jats:p>Results.\u2014Subcutaneous sumatriptan, but not placebo, significantly decreased VAS from 8.3 \u00b1 2.1 to 2.4 \u00b1 3.0 cm (mean \u00b1 SD). The number of patients who described their pain as moderately or slightly better was 20 in the sumatriptan group and 1 in the placebo group. The effect of subcutaneous sumatriptan persisted for a median period of 7.9 hours (range: 1\u201320 hours).<\/jats:p>\n                  <jats:p>Conclusions.\u2014Subcutaneous sumatriptan produced prompt analgesia without serious adverse reactions in patients with trigeminal neuralgia refractory to previous treatment.<\/jats:p>","DOI":"10.1111\/j.1526-4610.2006.00405.x","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T06:51:49Z","timestamp":1144219909000},"page":"577-582","source":"Crossref","is-referenced-by-count":57,"title":["Subcutaneous Sumatriptan for Refractory Trigeminal Neuralgia"],"prefix":"10.1111","volume":"46","author":[{"given":"Akifumi","family":"Kanai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwako","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumio","family":"Hoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90086-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.5_suppl_2.S14"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1987.tb05780.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90148-B"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.11.1536"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198108000-00001"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100043225"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.12.2347"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0026-895X(25)09209-0","article-title":"Differential expression of sumatriptan\u2010sensitive 5\u2010hydroxy\u2010tryptamine receptors in human trigeminal ganglia and cerebral blood vessels","volume":"50","author":"Bouchelet I","year":"1996","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00475-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1989.hed2907420.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06711-3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000116756"},{"key":"e_1_2_6_15_2","first-page":"287","article-title":"Peripheral mechanisms for the initiation of pain following trigeminal nerve injury","volume":"18","author":"Robinson PP","year":"2004","journal-title":"J Orofac Pain"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-07-02468.1988"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90074-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230214"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1997.3704211.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1998.1805278.x"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1526-4610.2006.00405.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1526-4610.2006.00405.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:44:07Z","timestamp":1762069447000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/j.1526-4610.2006.00405.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1526-4610.2006.00405.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1526-4610.2006.00405.x","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}