{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:22:26Z","timestamp":1762100546648,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T00:00:00Z","timestamp":1152144000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>Objective.\u2014To assess whether the infarction topography influenced upon the incidence of headache and the likelihood of neurological recovery in lacunar infarction.<\/jats:p>\n                  <jats:p>Background.\u2014The relationship between topography of infarction and the incidence of headache as well as the influence of headache on neurological outcome in patients with lacunar stroke are still unclear.<\/jats:p>\n                  <jats:p>Methods.\u2014In a cohort of 387 patients with neuroimaging\u2010proven acute lacunar infarction collected from a prospective hospital\u2010based stroke registry over a 12\u2010year period, 43 patients (11.1%) presented with headache within a 72\u2010hour interval of stroke onset.<\/jats:p>\n                  <jats:p>\n                    Results.\u2014Headache was more common in deep brain gray matter or brainstem lacunar infarction than in supratentorial white matter lacunar infarction (14.9% vs 8%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .033), but lacunar infarctions in the supratentorial white matter had less frequently absence of limitation at discharge (15.1% vs 25.1%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .013). In deep brain gray matter or brainstem lacunar infarction, early neurological recovery decreased from 26.2% to 19.2% when headache was present at stroke onset. In the multivariate analysis, dysarthria\u2010clumsy hand and absence of headache in deep brain gray matter or brainstem lacunar infarction were independent predictors of favorable outcome.\n                  <\/jats:p>\n                  <jats:p>Conclusions.\u2014In patients with lacunar infarction, headache at stroke onset was more common in deep brain gray matter or brainstem topographies than in supratentorial white matter lesions. In deep brain gray matter or brainstem lacunar infarctions, early neurological recovery was less likely when headache was present.<\/jats:p>","DOI":"10.1111\/j.1526-4610.2006.00507.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T11:15:47Z","timestamp":1152270947000},"page":"1172-1180","source":"Crossref","is-referenced-by-count":19,"title":["Clinical Implications of Headache in Lacunar Stroke: Relevance of Site of 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