{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:06:24Z","timestamp":1768075584036,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T00:00:00Z","timestamp":1197331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives.\u2014<\/jats:bold>\n                    To describe a large multigenerational family with migraine\u2010associated vertigo (MAV) combining a detailed phenotypic and genetic analysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Background.\u2014<\/jats:bold>\n                    Migraine\u2010associated vertigo is said to be highly prevalent in the general population and, like other migraine syndromes, its etiology is felt to have a strong genetic component. However, so far, there have been no reports of large families with MAV.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods.\u2014<\/jats:bold>\n                    Detailed clinical study was conducted on a large multigenerational family with MAV. Genetic study using identical\u2010by\u2010descent analysis with dense single nucleotide polymorphism (SNP) arrays was performed to examine consistent inheritance pattern among the affecteds.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.\u2014<\/jats:bold>\n                    Clinical features of MAV were variable although most had other migraine symptoms with at least some of their attacks. We did not find a region of the genome shared by all eight subjects with MAV indicating a polygenetic inheritance for MAV even in this single large family.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.\u2014<\/jats:bold>\n                    A region on 11q shared by most affected females may contain a susceptibility allele for MAV that is expressed exclusively or predominantly by women.\n                  <\/jats:p>","DOI":"10.1111\/j.1526-4610.2007.01002.x","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T12:57:56Z","timestamp":1227099476000},"page":"1460-1467","source":"Crossref","is-referenced-by-count":40,"title":["Phenotypic and Genetic Analysis of a Large Family With Migraine\u2010Associated Vertigo"],"prefix":"10.1111","volume":"48","author":[{"given":"Hane","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna C.","family":"Jen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon\u2010Hee","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley F.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Baloh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,11,19]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"On Megrim: Sick Headache and Some Allied Health Disorders: A Contribution to the Pathology of Nerve Storms","author":"Liveing E","year":"1873"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1993.hed3303125.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1981.hed2105227.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.436"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1704505.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00504.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.4.1123"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000275693"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1994.1406458.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1980.hed2006344.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.4.363"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2004.40.7.850476"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.52"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81373-2"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66786-4"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1081"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1986.0602101.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1306389.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00210307"},{"issue":"7","key":"e_1_2_7_21_2","first-page":"1","article-title":"Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain","volume":"8","author":"Headache Classification Committee of the International Headache Society","year":"1988","journal-title":"Cephalalgia"},{"key":"e_1_2_7_22_2","unstructured":"NelsonSF MerrimanB.Detecting identical\u2010by\u2010descent DNA intervals between affected distant relatives using high\u2010density SNP genotyping. In 55th Annual American Society of Human Genetics Meeting Salt Lake City UT 2005."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593-11"},{"key":"e_1_2_7_24_2","first-page":"1323","article-title":"Descent graphs in pedigree analysis: Applications to haplotyping, location scores, and marker\u2010sharing statistics","volume":"58","author":"Sobel E","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328013f432"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480010072027"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1294"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510003165"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-004-0205-0"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/444510"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/339078"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01228.x"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1526-4610.2007.01002.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1526-4610.2007.01002.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:02:04Z","timestamp":1762074124000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/j.1526-4610.2007.01002.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1111\/j.1526-4610.2007.01002.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1526-4610.2007.01002.x","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}