{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:00:26Z","timestamp":1787014826869,"version":"build-2736575974"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1584,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Med"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1111\/j.1526-4637.2011.01102.x","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T04:25:48Z","timestamp":1302582348000},"page":"782-793","source":"Crossref","is-referenced-by-count":13,"title":["Insulin Implants Prevent the Temporal Development of Mechanical Allodynia and Opioid Hyposensitivity for 24-Wks in Streptozotocin (STZ)-Diabetic Wistar Rats"],"prefix":"10.1093","volume":"12","author":[{"given":"Kathleen J.","family":"Otto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Cabot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maree T.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"2016011903154104000_12.5.782.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70319-1"},{"key":"2016011903154104000_12.5.782.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2006.05.004"},{"key":"2016011903154104000_12.5.782.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.05.006"},{"key":"2016011903154104000_12.5.782.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2008.00309.x"},{"key":"2016011903154104000_12.5.782.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-543X.2005.00110.x"},{"key":"2016011903154104000_12.5.782.6","doi-asserted-by":"publisher","DOI":"10.1002\/1520-7560(200011\/12)16:6<408::AID-DMRR158>3.0.CO;2-R"},{"key":"2016011903154104000_12.5.782.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"2016011903154104000_12.5.782.8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ajhp\/61.2.160","article-title":"Diabetic neuropathy: An intensive review","volume":"61","author":"Duby","year":"2004","journal-title":"Am J Health Syst Pharm"},{"key":"2016011903154104000_12.5.782.9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.075119"},{"key":"2016011903154104000_12.5.782.10","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90198-4"},{"key":"2016011903154104000_12.5.782.11","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90012-M"},{"key":"2016011903154104000_12.5.782.12","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200009001-00003"},{"key":"2016011903154104000_12.5.782.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00596-4"},{"key":"2016011903154104000_12.5.782.14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0022-3565(24)37362-8","article-title":"Is the reduced efficacy of morphine in diabetic rats caused by alterations of opiate receptors or of morphine pharmacokinetics?","volume":"285","author":"Courteix","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"2016011903154104000_12.5.782.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00172-9"},{"key":"2016011903154104000_12.5.782.16","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200212000-00037"},{"key":"2016011903154104000_12.5.782.17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90655-S"},{"key":"2016011903154104000_12.5.782.18","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90729-3"},{"key":"2016011903154104000_12.5.782.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00386-9"},{"key":"2016011903154104000_12.5.782.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01593-X"},{"key":"2016011903154104000_12.5.782.21","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2005.8.386"},{"key":"2016011903154104000_12.5.782.22","first-page":"443","article-title":"Effect of hyperglycemia on the efficacy of morphine analgesia in rats","volume":"35","author":"Ibironke","year":"2006","journal-title":"Afr J Med Med Sci"},{"key":"2016011903154104000_12.5.782.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.02.002"},{"key":"2016011903154104000_12.5.782.24","first-page":"654","article-title":"Involvement of p38 MAPkinase in attenuation of antinociceptive effect of morphine in diabetic mice","volume":"45","author":"Gilhotra","year":"2007","journal-title":"Indian J Exp Biol"},{"key":"2016011903154104000_12.5.782.25","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.121.5.965"},{"key":"2016011903154104000_12.5.782.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2006.09.015"},{"key":"2016011903154104000_12.5.782.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.12.035"},{"key":"2016011903154104000_12.5.782.28","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000057720.36503.2C"},{"key":"2016011903154104000_12.5.782.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00160-X"},{"key":"2016011903154104000_12.5.782.30","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.12.2407"},{"key":"2016011903154104000_12.5.782.31","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1237"},{"key":"2016011903154104000_12.5.782.32","doi-asserted-by":"publisher","DOI":"10.1042\/bj3560031"},{"key":"2016011903154104000_12.5.782.33","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051564"},{"key":"2016011903154104000_12.5.782.34","doi-asserted-by":"publisher","DOI":"10.1159\/000139268"},{"key":"2016011903154104000_12.5.782.35","first-page":"536","article-title":"The mechanism of alloxan and streptozotocin action in \u03b2 cells of the rat pancreas","volume":"50","author":"Szkudelski","year":"2001","journal-title":"Physiol Res"},{"key":"2016011903154104000_12.5.782.36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04622.x"},{"key":"2016011903154104000_12.5.782.37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2006.04515.x"},{"key":"2016011903154104000_12.5.782.38","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90059-X"},{"key":"2016011903154104000_12.5.782.39","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1152\/jn.1994.72.2.684","article-title":"Protein kinase C inhibitors decrease hyperalgesia and C-fibre hyperexcitability in the streptozotocin-diabetic rat","volume":"72","author":"Ahlgren","year":"1994","journal-title":"J Neurophysiol"},{"key":"2016011903154104000_12.5.782.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00024-X"},{"key":"2016011903154104000_12.5.782.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03828-3"},{"key":"2016011903154104000_12.5.782.42","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.123018"},{"key":"2016011903154104000_12.5.782.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.05.055"},{"key":"2016011903154104000_12.5.782.44","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.990"},{"key":"2016011903154104000_12.5.782.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.02.087"},{"key":"2016011903154104000_12.5.782.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.09.013"},{"key":"2016011903154104000_12.5.782.47","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-9"},{"key":"2016011903154104000_12.5.782.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.10.016"},{"key":"2016011903154104000_12.5.782.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.03.022"},{"key":"2016011903154104000_12.5.782.50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01067.x"},{"key":"2016011903154104000_12.5.782.51","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.32.3.16"},{"key":"2016011903154104000_12.5.782.52","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-005-0197-8"},{"key":"2016011903154104000_12.5.782.53","first-page":"H1840","article-title":"Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension","volume":"294","author":"Lesniewski","year":"2008","journal-title":"Am J Physiol"},{"key":"2016011903154104000_12.5.782.54","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1099-0461(1998)12:4<219::AID-JBT4>3.0.CO;2-O","article-title":"Streptozotocin-induced diabetes increases \u03b3-glutamyltranspeptidase activity but not expression in rat liver","volume":"12","author":"Watkins","year":"1998","journal-title":"J Biochem Mol Toxicol"},{"key":"2016011903154104000_12.5.782.55","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00284.x"},{"key":"2016011903154104000_12.5.782.56","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-004-1339-0"},{"key":"2016011903154104000_12.5.782.57","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-008-0038-7"},{"key":"2016011903154104000_12.5.782.58","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1590\/S0100-879X2009000200008","article-title":"Streptozotocin-induced mechanical hypernociception is not dependent on hyperglycemia","volume":"42","author":"Cunha","year":"2009","journal-title":"Braz J Med Biol Res"},{"key":"2016011903154104000_12.5.782.59","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-38"},{"key":"2016011903154104000_12.5.782.60","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(00)00230-5"},{"key":"2016011903154104000_12.5.782.61","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220612"},{"key":"2016011903154104000_12.5.782.62","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706754"},{"key":"2016011903154104000_12.5.782.63","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.68.413"},{"key":"2016011903154104000_12.5.782.64","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03201-0"},{"key":"2016011903154104000_12.5.782.65","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.8.2129"},{"key":"2016011903154104000_12.5.782.66","first-page":"F673","article-title":"Reduced IP receptors in STZ-induced diabetic rat kidneys and high-glucose-treated mesangial cells","volume":"287","author":"Nasrallah","year":"2004","journal-title":"Am J Physiol"},{"key":"2016011903154104000_12.5.782.67","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"2016011903154104000_12.5.782.68","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701538"},{"key":"2016011903154104000_12.5.782.69","unstructured":"Charles River Laboratories. Wistar rat. Animal Research Models. Available at: http:\/\/www.criver.com\/en-US\/ProdServ\/ByType\/ResModOver\/ResMod\/Pages\/WistarRat.aspx (accessed March 14, 2011)."},{"key":"2016011903154104000_12.5.782.70","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199608120-00010"},{"key":"2016011903154104000_12.5.782.71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2004.009204.x"},{"key":"2016011903154104000_12.5.782.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.07.009"},{"key":"2016011903154104000_12.5.782.73","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(99)00034-3"},{"key":"2016011903154104000_12.5.782.74","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.903"},{"key":"2016011903154104000_12.5.782.75","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1162"},{"key":"2016011903154104000_12.5.782.76","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"2016011903154104000_12.5.782.77","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07037-8"},{"key":"2016011903154104000_12.5.782.78","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0129"},{"key":"2016011903154104000_12.5.782.79","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0022-3565(24)37002-8","article-title":"Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy","volume":"283","author":"Zhuang","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"2016011903154104000_12.5.782.80","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.115"},{"key":"2016011903154104000_12.5.782.81","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200301000-00033"},{"key":"2016011903154104000_12.5.782.82","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1152\/jn.2001.86.2.760","article-title":"Impaired inhibitory G-protein function contributes to increased calcium currents in rats with diabetic neuropathy","volume":"86","author":"Hall","year":"2001","journal-title":"J Neurophysiol"},{"key":"2016011903154104000_12.5.782.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.025"},{"key":"2016011903154104000_12.5.782.84","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00354-5"},{"key":"2016011903154104000_12.5.782.85","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01365-4"},{"key":"2016011903154104000_12.5.782.86","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00020-X"},{"key":"2016011903154104000_12.5.782.87","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-005-6154-y"},{"key":"2016011903154104000_12.5.782.88","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0040621"},{"key":"2016011903154104000_12.5.782.89","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00093-6"}],"container-title":["Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/painmedicine\/article-pdf\/12\/5\/782\/5390300\/12-5-782.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T19:50:53Z","timestamp":1741117853000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/painmedicine\/article-lookup\/doi\/10.1111\/j.1526-4637.2011.01102.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":89,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,5,1]]},"published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1111\/j.1526-4637.2011.01102.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1526-4637.2011.01102.x","relation":{},"ISSN":["1526-2375","1526-4637"],"issn-type":[{"value":"1526-2375","type":"print"},{"value":"1526-4637","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}