{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:46:45Z","timestamp":1790063205906,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T00:00:00Z","timestamp":1181606400000},"content-version":"vor","delay-in-days":1684,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congestive Heart Failure"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p> <jats:italic>In heart failure, sodium is retained by the kidneys despite increases in extracellular volume. There is activation of renin secretion, which culminates in the production of angiotensin II, causing vasoconstriction and aldosterone secretion. These synergistically produce an increase in tubular reabsorption of sodium and water. Diuretics are the mainstay of symptomatic treatment to remove excess extracellular fluid in heart failure. Diuretics that affect the ascending loop of Henle are most commonly used. Thiazide diuretics promote a much greater natriuretic effect when combined with a loop diuretic in patients with refractory edema. Recently, spironolactone, an aldosterone receptor blocking agent, has been recommended to attenuate some of the neurohormonal effects of heart failure. Regardless of the diuretic, patients need to be counseled on the importance of avoiding sodium in their diet<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1527-5299.2002.00700.x","type":"journal-article","created":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T11:20:18Z","timestamp":1181647218000},"page":"307-312","source":"Crossref","is-referenced-by-count":19,"title":["Balancing Diuretic Therapy in Heart Failure: Loop Diuretics, Thiazides, and Aldosterone Antagonists"],"prefix":"10.1111","volume":"8","author":[{"given":"Sara","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,12]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1896.sp000596"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194001000-00005"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194001000-00004"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1944.00210140028004"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101720"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(49)90173-4"},{"key":"e_1_2_3_8_2","first-page":"155","volume-title":"Heart Failure: Scientific Principles and Clinical Practice","author":"Anand I","year":"1997"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.2.299"},{"key":"e_1_2_3_10_2","first-page":"F1269","article-title":"Adaptation of distal tubule and collecting duct to increased sodium delivery, II. Sodium and potassium transport","volume":"255","author":"Stanton B","year":"1988","journal-title":"Am J Physiol"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.43"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.3.298"},{"key":"e_1_2_3_13_2","first-page":"82","article-title":"Regulation of sodium and potassium transport by mineralocorticoids","volume":"7","author":"Stanton B","year":"1987","journal-title":"Semin Nephron"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113059"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197305242882102"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1847"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.5.491"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.5.630"},{"key":"e_1_2_3_19_2","first-page":"221","article-title":"The role of the kidney in the early nondiuretic action of furosemide to reduce elevated left atrial pressure in the hypervolemic dog","volume":"202","author":"Bourland W","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_3_20_2","first-page":"F779","article-title":"Effects of prostaglandins and vasoconstrictor action in isolated renal arterioles","volume":"248","author":"Edwards R","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90906-X"},{"key":"e_1_2_3_22_2","first-page":"386","article-title":"Analysis of the effect of indomethacin on the response to furosemide in man: effect of dose of furosemide","volume":"210","author":"Brater D","year":"1979","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70272-X"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-1-1"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"key":"e_1_2_3_26_2","first-page":"1","article-title":"Treatment of refractory edema","volume":"8","author":"Rose B","year":"2000","journal-title":"Up To Date CD ROM"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00365-9"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.153"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-3-314"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.149"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00161-1"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-360"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6532.1351"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90854-3"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1985.tb00179.x"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-3-405"},{"key":"e_1_2_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)80003-8"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"e_1_2_3_39_2","first-page":"11","article-title":"Heart Failure Society of America. Guidelines for the management of patients with heart failure due to left ventricular systolic dysfunction: Pharmacological approaches","volume":"6","year":"2000","journal-title":"Congest Heart Fail"}],"container-title":["Congestive Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1527-5299.2002.00700.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1527-5299.2002.00700.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T16:38:02Z","timestamp":1697560682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1527-5299.2002.00700.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1111\/j.1527-5299.2002.00700.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1527-5299.2002.00700.x","archive":["Portico"],"relation":{},"ISSN":["1527-5299","1751-7133"],"issn-type":[{"value":"1527-5299","type":"print"},{"value":"1751-7133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}