{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:09:11Z","timestamp":1760954951989},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T00:00:00Z","timestamp":1172188800000},"content-version":"vor","delay-in-days":602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congestive Heart Failure"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p> <jats:italic>Continuous flow pumps are increasingly used to treat severe heart failure. These pumps alter flow physiology by lowering pulsatility in the arterial circulation. In patients with peripheral stenosis, continuous flow pumps may lead to thrombosis of peripheral vessels, possibly predisposing to vascular thrombosis in areas of non\u2010flow\u2010limiting stenosis. The authors performed a computerized flow modeling simulation to analyze the effects of altered hemodynamics in a stenotic area. Drawing on previous clinical experience, we modeled a stenotic area in the common carotid artery. Computerized flow modeling revealed blood stagnation zones with low shear stress and velocity adjacent to the stenotic area during nonpulsatile flow. Such stagnation was not present during pulsatile flow. These results indicate a mechanism by which altered physiologic flow may accelerate occlusion of arterial conduits in patients with preexisting stenosis. This finding may be important for patients with continuous flow devices who have peripheral vascular disease; therefore, further study is warranted.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1527-5299.2005.04474.x","type":"journal-article","created":{"date-parts":[[2007,2,24]],"date-time":"2007-02-24T04:14:58Z","timestamp":1172290498000},"page":"182-187","source":"Crossref","is-referenced-by-count":10,"title":["Vascular Thrombosis During Support With Continuous Flow Ventricular Assist Devices: Correlation With Computerized Flow Simulations"],"prefix":"10.1111","volume":"11","author":[{"given":"Biswajit","family":"Kar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Reynolds M.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branislav","family":"Radovancevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Wadia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George V.","family":"Letsou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Riaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Gregoric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.","family":"Harting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.255.14.1892"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)90393-I"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-6296(87)90013-5"},{"key":"e_1_2_6_5_2","first-page":"126","article-title":"Effects of severity and eccentricity of stenosis on blood flow in the carotid artery bifurcation","volume":"46","author":"Metcalfe R","year":"2001","journal-title":"Bull Am Physical Soc"},{"key":"e_1_2_6_6_2","volume-title":"Proceedings of the Second Joint Meeting of the IEEE Engineering in Medicine & Biology Society and the Biomedical Engineering Society","author":"Metcalfe R","year":"2002"},{"key":"e_1_2_6_7_2","volume-title":"Effects of Severity and Eccentricity of Stenosis on Blood Flow in the Carotid Artery Bifurcation","author":"Lundin S","year":"2000"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(82)90057-4"},{"key":"e_1_2_6_9_2","first-page":"293","article-title":"Pulsatile flow and atherosclerosis in the human carotid bifurcation. 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