{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:12:35Z","timestamp":1760170355075},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T00:00:00Z","timestamp":1170028800000},"content-version":"vor","delay-in-days":150,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congestive Heart Failure"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p> <jats:italic>The authors used brain natriuretic peptide (BNP) as a reliable marker to identify nonresponders to cardiac resynchronization therapy (CRT) in patients with advanced heart failure. The study included 70 patients with left ventricular dysfunction (mean ejection fraction, 21\u00b14%) and left bundle branch block (QRS duration, 164\u00b125 milliseconds) treated with CRT. The authors reviewed data on New York Heart Association functional class, baseline ejection fraction, sodium, creatinine, QRS duration, and BNP levels 3 months before and after CRT therapy. The authors compared results of 42 patients who survived (973+192 days) after CRT implantation (responders) to those of 28 patients (nonresponders) who either expired (n=21) or underwent heart transplantation (n=5) or left ventricular assist device implantation (n=2) after an average of 371+220 days. Mean BNP levels after 3 months of CRT decreased in responders from 758\u00b1611 pg\/mLto 479\u00b1451 pg\/mL<\/jats:italic> (P<jats:italic>=.044), while in nonresponders there was increase in BNP levels from 1191 \u00b1466 pg\/mL to 1611 \u00b11583;<\/jats:italic> P<jats:italic>=.046. A rise in BNP levels was associated with poor response (death or need for transplantation or left ventricular assist device and impaired long\u2010term outcome), which makes it a good predictor to identify such patients.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1527-5299.2006.05469.x","type":"journal-article","created":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T08:38:42Z","timestamp":1170059922000},"page":"250-253","source":"Crossref","is-referenced-by-count":16,"title":["Brain Natriuretic Peptide Levels and Response to Cardiac Resynchronization Therapy in Heart Failure Patients"],"prefix":"10.1111","volume":"12","author":[{"given":"Reynolds M.","family":"Delgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanthini","family":"Palanichamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajko","family":"Radovancevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojan","family":"Vrtotec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branislav","family":"Radovancevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2685"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441202"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02240-8"},{"key":"e_1_2_6_6_2","first-page":"l","article-title":"Echocardiographic evaluation of cardiac resynchronization therapy: ready for routine clinical use","volume":"44","author":"Bax JJ","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03404-5"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.06.016"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","unstructured":"DoshiRN.Optimizing resynchronization therapy: can we increase the number of true responders? 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