{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:36:31Z","timestamp":1790627791394,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T00:00:00Z","timestamp":1170028800000},"content-version":"vor","delay-in-days":212,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Congestive Heart Failure"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p> <jats:italic>Evidence of racial differences in aldosterone concentrations and K+ disposition suggests that response to aldosterone antagonism might vary by race. The authors sought to determine whether K+ response to spironolactone differs between African Americans and Caucasians with heart failure. Heart failure patients of African\u2010American (n=34) or Caucasian (n=17) race were started on spironolactone 12.5 mg\/d, with up\u2010titration as tolerated. Laboratory values and drug therapy were similar between racial groups at baseline. Spironolactone was titrated to a median dose of 25 mg\/d in both groups. Neither concomitant medications nor serum creatinine changed significantly in either group during spironolactone dose titration. Median serum K+ concentrations increased by 0.5 mEq\/L (range, \u22120.7 to 1.6 mEq\/L) in Caucasians, but only 0.1 mEq\/L (range, \u22120.8 to 0.9 mEq\/L) in African Americans;<\/jats:italic> p<jats:italic>&lt;0.01. These data suggest that African Americans with heart failure may be less responsive to the renal effects of spironolactone.<\/jats:italic><\/jats:p>","DOI":"10.1111\/j.1527-5299.2006.05502.x","type":"journal-article","created":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T08:40:42Z","timestamp":1170060042000},"page":"200-205","source":"Crossref","is-referenced-by-count":9,"title":["Racial Differences in Potassium Response to Spironolactone in Heart Failure"],"prefix":"10.1111","volume":"12","author":[{"given":"Larisa H.","family":"Cavallari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki L.","family":"Groo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Momary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deidra","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlos A.G.","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Vaitkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,29]]},"container-title":["Congestive Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1527-5299.2006.05502.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1527-5299.2006.05502.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1527-5299.2006.05502.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:47:17Z","timestamp":1694425637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1527-5299.2006.05502.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1527-5299.2006.05502.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1527-5299.2006.05502.x","archive":["Portico"],"relation":{},"ISSN":["1527-5299","1751-7133"],"issn-type":[{"value":"1527-5299","type":"print"},{"value":"1751-7133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}