{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:23:29Z","timestamp":1778747009749,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T00:00:00Z","timestamp":1194220800000},"content-version":"vor","delay-in-days":6851,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>Summary: <\/jats:bold> The research literature is consistent in reporting somewhat less familial aggregation in partial than in generalized epilepsy. However, relatives of patients with partial seizures do appear to have higher seizure risks than relatives of controls, suggesting that genetic factors are important in at least some partial epilepsies. <jats:italic>Complex partial<\/jats:italic> epilepsy appears to be only slightly less familial than other types of epilepsy. Relatives of patients with focal EEG abnormalities generally have been found to have lower risk of both EEG abnormalities and epilepsy than relatives of patients with generalized abnormalities. For focal <jats:italic>temporocentral<\/jats:italic> abnormalities, however, there is evidence of an important influence of genetic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>R\u00c9SUM\u00c9<\/jats:title><jats:p>La litt\u00e9rature rapporte de fa\u00e7on concordante un caract\u00e8re familial moins prononc\u00e9 dans les \u00e9pilepsies partielles que dans les epilepsies g\u00e9n\u00e9ralis\u00e9es. Cependant. les parents de patients pr\u00e9sentant des crises partielles pr\u00e9sentent bien des risques sup\u00e9rieurs pour \u00e9pilepsie que les parents de sujets contr\u00f4les: ceci sugg\u00e8re que les facteurs g\u00e9n\u00e9iques jouent un r\u00f4le important dans au moins une partie des \u00e9pilepsies partielles. Les \u00e9pilepsies partielles complexes semblent avoir un caract\u00e8re familial \u00e0 peine moins prononc\u00e9 que autres types \u00e9pilepsies. Chez les parents de sujets pr\u00e9sentant des anomalies EEG focales, on a constat\u00e9 en g\u00e9n\u00e9ral que le risque de pr\u00e9senter \u00e0 la fois des anomalies EEG focales et une \u00e9pilepsie \u00e9tait moindre que chez les parents de sujets pr\u00e9sentant une \u00e9pilepsie g\u00e9n\u00e9ralis\u00e9e. En ce qui concerne les anomalies focales centro\u2010temporales, il y a cependant des preuves une influence importante de facteurs g\u00e9n\u00e9tiques.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESUMEN<\/jats:title><jats:p>En la literatura se insiste de modo persistente que existe una agregaci\u00f3n familiar menos importante en las epileps\u00edas parciales que en la epilepsia generalizada. Sin embargo, se ha observado que familiares de enfermos con ataques parciales tienen un riesgo m\u00e1s elevado de ataques que los familiares de los controles, lo que sugiere la importancia de factores gen\u00e9ticos en, al menos, algunas formas de epileps\u00edas parciales. La epileps\u00eda parcial compleja parece ser algo menos familiar que otros tipos de epileps\u00eda. Los familiares de enfermos con anormalidades focales del EEG. generalmente tienen un riesgo menor de tener anomal\u00edas en el EEG o de sufrir epilepsia que los familiares de aquellos casos con anomal\u00edas generalizadas. Sin embargo, en aquellos casos de anomal\u00edas centro\u2010temporales, existe importante eviden\u2010cia de posibles influencias de factores gen\u00e9ticos.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1528-1157.1989.tb05290.x","type":"journal-article","created":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T19:20:29Z","timestamp":1194290429000},"page":"107-111","source":"Crossref","is-referenced-by-count":51,"title":["Genetics of the Partial Epilepsies: A Review"],"prefix":"10.1111","volume":"30","author":[{"given":"Ruth","family":"Ottman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"348","article-title":"A multifactorial analysis of focal and generalized cortico\u2010reticular (centrencephalic) epilepsy","volume":"13","author":"Andermann E.","year":"1972","journal-title":"Epilepsia"},{"key":"e_1_2_1_3_1","first-page":"78","volume-title":"Genetic counseling for epilepsy. 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