{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:53:08Z","timestamp":1783774388223,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T00:00:00Z","timestamp":1141603200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> Defining prognostic factors for neocortical epilepsy surgery is important for the identification of ideal candidates and for predicting the prognosis of individual patients. We use multivariate analysis to identify favorable prognostic factors for neocortical epilepsy surgery.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> One hundred ninety\u2010three neocortical epilepsy patients, including 91 without focal lesions on MRI, were included. Sixty\u2010one had frontal lobe epilepsy (FLE), 80 had neocortical temporal lobe epilepsy (nTLE), 21 had parietal lobe epilepsy (PLE), and 22 had occipital lobe epilepsy (OLE). The primary outcome variable was patient status \u22652 years after surgery (i.e., seizure free or not). Clinical characteristics and the recent presurgical diagnostic modalities were considered as probable prognostic factors. Univariate and standard multiple logistic regression analyses were used to identify favorable prognostic factors.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> The seizure\u2010free rate was 57.5%. By univariate analysis, a focal lesion on MRI, localized ictal onset on surface EEG, epilepsies other than FLE, localized hypometabolism on fluorodeoxyglucose\u2013positron emission tomography (FDG\u2010PET), and pathologies other than cortical dysplasia were significantly associated with a seizure\u2010free outcome (p &lt; 0.05). Multivariate analysis revealed that a focal lesion on MRI (p = 0.003), correct localization by FDG\u2010PET (p = 0.007), and localized ictal onset on EEG (p = 0.01) were independent predictors of a good outcome.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> The presence of a focal lesion on MRI, correct localized hypometabolism on FDG\u2010PET, or localized ictal rhythms on EEG were identified as predictors of a seizure\u2010free outcome. Our results suggest that these findings allow the selection of better candidates for neocortical epilepsy surgery.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2006.00470.x","type":"journal-article","created":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T09:10:53Z","timestamp":1141636253000},"page":"574-579","source":"Crossref","is-referenced-by-count":143,"title":["Prognostic Factors in Neocortical Epilepsy Surgery: Multivariate Analysis"],"prefix":"10.1111","volume":"47","author":[{"given":"Chang\u2010Ho","family":"Yun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Kun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang 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