{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:59:28Z","timestamp":1776153568140,"version":"3.50.1"},"reference-count":96,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T00:00:00Z","timestamp":1147046400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> Zinc chelation with diethyldithiocarbamate (DEDTC) during nondamaging kainic acid administration enhances excitotoxicity to the level of cell damage. The objective of this work was to study the developing of the lesion in this model of temporal lobe epilepsy and the implications of the different types of glutamate receptors.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> The antagonist of the <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (NMDA) receptor MK\u2010801, and the antagonist of the \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazolepropionate (AMPA) receptor GYKI52466, were used concomitantly with intraperitoneal administration of kainic acid (15 mg\/kg) followed by DEDTC (150 mg\/kg) in mouse. The animals were killed at different times from 4 h to 7 days. Fos proteins were used as markers of cell overexcitation; heat\u2010shock protein 72 (HSP72) as marker of cell stress.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Neither kainic acid nor DEDTC alone, at the doses used, led to cell loss, HSP72 expression, or permanent Fos protein induction. When combined, the hilus and cornu ammonis were damaged; principal cells in these areas coexpressed c\u2010Fos and HSP72, with the exception of CA2; interneurons did not express HSP72 in any area. MK\u2010801 completely abolished damage and HSP72 expression from the hippocampus. GYKI52466 blocked CA1 damage and HSP72 expression in the CA1 but not in the CA3.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> Synaptic zinc increases the tolerance of hippocampus to overexcitation. All the areas that are fated to die are determined simultaneously; the damage in the CA1 is not an extension of the damage in the CA3. Damage of the CA3 is dependent on kainate and NMDA receptors, whereas the damage of the CA1 depends on AMPA and NMDA receptors.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2006.00501.x","type":"journal-article","created":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T09:34:54Z","timestamp":1147080894000},"page":"887-899","source":"Crossref","is-referenced-by-count":22,"title":["Neural Overexcitation and Implication of NMDA and AMPA Receptors in a Mouse Model of Temporal Lobe Epilepsy Implying Zinc Chelation"],"prefix":"10.1111","volume":"47","author":[{"given":"Mar\u00eda\u2010Isabel","family":"Dom\u00ednguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9\u2010Miguel","family":"Blasco\u2010Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Nacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana\u2010Isabel","family":"Marqu\u00e9s\u2010Mar\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco\u2010Jos\u00e9","family":"Mart\u00ednez\u2010Guijarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401978"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91612-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00490264"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61242-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90494-M"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.8.823"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109536"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.23.12676"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01191734"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199210000-00010"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/308734a0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/308736a0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238969"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91355-2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81149-6"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1523\/JNEUROSCI.21-20-08015.2001","article-title":"Induction of mossy fiber: Ca3 long\u2010term potentiation requires translocation of synaptically released Zn2+","volume":"21","author":"Li Y","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200204066"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.089276"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.07.054"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90017-4"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90899-2"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90199-6"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90045-4"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90806-M"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91271-2"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199507310-00024"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.1990.tb06298.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1671"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(99)00121-7"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01610-6"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)90082-5"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858404263463"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00731-5"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91006-3"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90242-J"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90253-8"},{"key":"e_1_2_6_38_2","first-page":"127","article-title":"Neuroprotective effect of GYKI 52466 on AMPA\u2010induced neurotoxicity in rat striatum","volume":"6","author":"Bartha E","year":"1998","journal-title":"Neurobiology B"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(91)90018-B"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90342-N"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90164-3"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.35504.x"},{"key":"e_1_2_6_43_2","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1523\/JNEUROSCI.17-14-05407.1997","article-title":"Absence of a persistently elevated 37 kDa fos\u2010related antigen and AP\u20101\u2010like DNA\u2010binding activity in the brains of kainic acid\u2010treated fosB null mice","volume":"17","author":"Mandelzys A","year":"1997","journal-title":"J Neurosci"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037702"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91357-M"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90024-6"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199312000-00022"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(89)90150-7"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199709)33:3<232::AID-NEU3>3.0.CO;2-2"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/363166a0"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)94495-Q"},{"key":"e_1_2_6_52_2","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1523\/JNEUROSCI.12-08-03004.1992","article-title":"Heat shock protein expression in vulnerable cells of the rat hippocampus as an indicator of excitation\u2010induced neuronal stress","volume":"12","author":"Sloviter RS","year":"1992","journal-title":"J Neurosci"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)92049-P"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490270302"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490250103"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(94)90058-2"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00313-8"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90369-V"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/328378a0"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440402"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01392-7"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90059-W"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90299-4"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/322552a0"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb12518.x"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(05)80013-0"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb44407.x"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3083508"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.3.629"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90452-5"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260113"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(90)90036-U"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00462-E"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90081-E"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90550-S"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-12-04637.1998"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.200.19.2565"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1998.00219.x"},{"key":"e_1_2_6_79_2","first-page":"501","article-title":"Some central effects of GYKI 52466, a non\u2010competitive AMPA receptor antagonist","volume":"47","author":"Maj J","year":"1995","journal-title":"Pol J Pharmacol"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-02-00653.1999"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90569-0"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.10.053"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91273-J"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(93)90012-D"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/309261a0"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/307462a0"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90334-C"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199512150-00025"},{"key":"e_1_2_6_89_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1996.061.01.041"},{"key":"e_1_2_6_90_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5264.1013"},{"key":"e_1_2_6_91_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00437.x"},{"key":"e_1_2_6_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2414"},{"key":"e_1_2_6_93_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00277.x"},{"key":"e_1_2_6_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01541-8"},{"key":"e_1_2_6_95_2","doi-asserted-by":"crossref","first-page":"10521","DOI":"10.1523\/JNEUROSCI.23-33-10521.2003","article-title":"Heterogeneity of Ca2+\u2010permeable AMPA\/kainate channel expression in hippocampal pyramidal neurons: fluorescence imaging and immunocytochemical assessment","volume":"23","author":"Ogoshi F","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_6_96_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1031598100"},{"key":"e_1_2_6_97_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.089458"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1528-1167.2006.00501.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1528-1167.2006.00501.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T13:11:56Z","timestamp":1697116316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1167.2006.00501.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":96,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1528-1167.2006.00501.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1528-1167.2006.00501.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}