{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:56:57Z","timestamp":1761512217221,"version":"3.32.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T00:00:00Z","timestamp":1144108800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold><jats:italic>Purpose:<\/jats:italic>Language\u2010induced epilepsy involves seizure precipitation by speaking, reading, and writing. Seizures are similar to those of reading epilepsy (RE). The nosologic position of language\u2010induced epilepsy is not clear. We performed a clinical and neurophysiological study in a multigenerational family with the association of idiopathic generalized epilepsy (IGE) with ictal stuttering as a manifestation of reflex language\u2010induced epilepsy.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic>Nine members on three generations were studied. All patients underwent video\u2010polygraphic EEG recordings (awake and during sleep). A standardized protocol was applied to test the effect of language and non\u2013language\u2010related tasks.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic>Six patients presented language\u2010induced jaw jerking that mimicked stuttering and corresponded to focal myoclonus involving facial muscles. This was associated with an IGE phenotype in four of these patients. Focal EEG spikes were found in all six patients by visual analysis and\/or back\u2010averaging techniques. The focal spikes were either asymptomatic (when followed by a slow wave) or symptomatic of facial myoclonia (when isolated). Levetiracetam, used as add\u2010on or monotherapy in four patients, suppressed ictal stuttering. One additional case only had a phenotype of IGE without focal features.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic>This family study demonstrates the phenotypic heterogeneity of the association of IGE phenotype with ictal stuttering (language\u2010related reflex seizure). Our data suggest that this particular form of reflex epilepsy related to language has more similarities with generalized epilepsies than with focal ones. Neurophysiological investigations should be performed more systematically in patients with acquired stuttering, especially if there is family history of IGE.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2006.00517.x","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T16:31:37Z","timestamp":1144168297000},"page":"766-772","source":"Crossref","is-referenced-by-count":16,"title":["Language\u2010induced Epilepsy, Acquired Stuttering, and Idiopathic Generalized Epilepsy: Phenotypic Study of One Family"],"prefix":"10.1111","volume":"47","author":[{"given":"Maria Paola","family":"Valenti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Rudolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Carr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Vrielynck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Thibault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Szepetowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470190029003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2002.tb00806.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1684\/j.1950-6945.2001.tb00385.x","article-title":"Symptomatic epilepsy with facial myoclonus triggered by language","volume":"3","author":"Canevini MP","year":"2001","journal-title":"Epileptic Disord"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.10401.x"},{"key":"e_1_2_6_6_2","first-page":"100","article-title":"Reading epilepsy: clinical and electroencephalographic studies of a new syndrome","volume":"81","author":"Bickford RG","year":"1956","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_6_7_2","first-page":"241","volume-title":"Reflex Epilepsies and Reflex Seizures: Advances in Neurology","author":"Ramani V","year":"1998"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.11.1051"},{"key":"e_1_2_6_9_2","first-page":"186","article-title":"Reading epilepsy in identical twins","volume":"98","author":"Forster FM","year":"1973","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000133208.57562.CB"},{"key":"e_1_2_6_12_2","first-page":"75","article-title":"Psychogenic stuttering in adults with and without neurologic disease","volume":"5","author":"Baumgartner J","year":"1997","journal-title":"J Med Speech Lang Pathol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1684\/j.1950-6945.2004.tb00067.x","article-title":"Stuttering or reflex seizures? 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