{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:55:03Z","timestamp":1761807303646},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T00:00:00Z","timestamp":1158710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose<\/jats:italic>: To determine whether epidural pentobarbital (PB) delivery can prevent and\/or terminate neocortical seizures induced by locally administered acetylcholine (Ach) in freely moving rats.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> Rats were implanted permanently with an epidural cup placed over the right parietal cortex with intact dura mater. Epidural screw\u2010electrodes, secured to the cup, recorded local neocortical EEG activity. In the seizure\u2010termination study, Ach was delivered into the epidural cup, and after the development of electrographic and behavioral seizures, the Ach solution was replaced with either PB or artificial cerebrospinal fluid (aCSF; control solution). In the seizure\u2010prevention study, the epidural Ach delivery was preceded by a 10\u2010min exposure of the delivery site to PB or aCSF. Raw EEG recordings, EEG power spectra, and behavioral events were analyzed.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Ach\u2010induced EEG seizures associated with convulsions, which were unaffected by epidural aCSF applications, were terminated by epidurally delivered PB within 2\u20132.5 min. Epidural deliveries of PB before Ach applications completely prevented the development of electrographic and behavioral seizures, whereas similar deliveries of aCSF exerted no influence on the seizure\u2010generating potential of Ach.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> This study showed for the first time that epidural AED delivery can prevent, as well as terminate, locally induced neocortical seizures. The findings support the viability of transmeningeal pharmacotherapy for the treatment of intractable neocortical epilepsy.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2006.00642.x","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T14:39:04Z","timestamp":1158763144000},"page":"1792-1802","source":"Crossref","is-referenced-by-count":28,"title":["Epidural Pentobarbital Delivery Can Prevent Locally Induced Neocortical Seizures in Rats: The Prospect of Transmeningeal Pharmacotherapy for Intractable Focal Epilepsy"],"prefix":"10.1111","volume":"47","author":[{"given":"Nandor","family":"Ludvig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben I.","family":"Kuzniecky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirn L.","family":"Baptiste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenine E.","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Von Gizycki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner K.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orrin","family":"Devinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01032-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(68)90046-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458506ms1232sr"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(89)90016-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh337"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01134.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(75)90137-5"},{"key":"e_1_2_6_9_1","unstructured":"FischellRE FischellDR AdrianRM. (2000)Responsive implantable system for the treatment of neurological disorders. <http:\/\/www.uspto.gov>. US Patent No.:6134474."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(63)90041-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(71)90266-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90077-X"},{"key":"e_1_2_6_13_1","first-page":"267","article-title":"Anticonvulsive effect of 2\u2010hydroxylamine\u20105\u2010ethyl\u20105\u2010sec\u2010pentyl barbituric acid (HB\u20107) in two experimental models of epilepsy","volume":"10","author":"Getova D","year":"1988","journal-title":"Methods and Findings in Experimental Clinical Pharmacology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199605000-00017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(00)00147-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.05.018"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.071332"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.10.013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.01.004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(02)70182-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00262-8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199506000-00019"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1988.tb03738.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(89)90022-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1996)6:2<97::AID-HIPO1>3.0.CO;2-4"},{"key":"e_1_2_6_26_1","first-page":"263","volume-title":"Neural prostheses for restoration of sensory and motor function","author":"Ludvig N","year":"2000"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00223-3"},{"key":"e_1_2_6_28_1","unstructured":"LudvigN KovacsL. (2002)Hybrid neuroprosthesis for the treatment of brain disorders. <http:\/\/www.uspto.gov>. US Patent No.: 6497699."},{"issue":"8","key":"e_1_2_6_29_1","first-page":"270","article-title":"Toward the development of a subdural hybrid neuroprosthesis for the treatment of intractable focal epilepsy","volume":"46","author":"Ludvig N","year":"2005","journal-title":"Epilepsia"},{"key":"e_1_2_6_30_1","first-page":"313","article-title":"The influence of pentobarbital upon a cortical epileptogenic focus in rats","volume":"226","author":"Mares P","year":"1977","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011315"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/54.10.1117"},{"key":"e_1_2_6_33_1","volume-title":"Clinical anesthesiology.","author":"Morgan GE","year":"2006"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199810000-00017"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.26004.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000066260.99680.11"},{"key":"e_1_2_6_37_1","volume-title":"The rat brain in stereotaxic coordinates.","author":"Paxinos G","year":"1998"},{"key":"e_1_2_6_38_1","first-page":"751","volume-title":"Intractable focal epilepsy.","author":"Polkey CE","year":"2000"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90177-0"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(83)90096-5"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(02)00052-9"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(99)00107-2"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(92)90063-W"},{"key":"e_1_2_6_44_1","first-page":"105","volume-title":"Modern neurosurgery: clinical translation of neuroscience advances.","author":"Turner DA","year":"2005"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01990130"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199607290-00019"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91178-2"},{"key":"e_1_2_6_48_1","first-page":"R104","article-title":"Neurotransmitter modulation of VIP release from cat cerebral cortex","volume":"250","author":"Wang JY","year":"1986","journal-title":"American Journal of Physiology"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.07.002"},{"issue":"8","key":"e_1_2_6_50_1","first-page":"226","article-title":"Safety and evidence for efficacy of an implantable responsive neurostimulator (RNS) for the treatment of medically intractable partial onset epilepsy in adults","volume":"46","author":"Worrell G","year":"2005","journal-title":"Epilepsia"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(87)90016-7"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1528-1167.2006.00642.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1528-1167.2006.00642.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T03:51:53Z","timestamp":1697341913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1167.2006.00642.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,2]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1528-1167.2006.00642.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1528-1167.2006.00642.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,2]]}}}