{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:32:22Z","timestamp":1784673142089,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:00:00Z","timestamp":1163635200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> To evaluate hypnotic and anticonvulsant activities of <jats:italic>Annona diversifolia<\/jats:italic> Saff. and palmitone by using behavior and electroencephalographic (EEG) analysis in an experimental model of focal seizures in rats.<\/jats:p><jats:p> <jats:italic>Methods<\/jats:italic>: For hypnotic assessment, EEG analysis of polysomnographic slow\u2010wave sleep (SWS) and rapid eye movement (REM) sleep for a 1 h period were performed after vehicle, <jats:italic>A. diversifolia<\/jats:italic> extract or palmitone, administration. For anticonvulsant effect, 60 minutes after treatments, EEG and behavior were analyzed during penicillin\u2010induced seizures. Latency to the onset of the first paroxystic spike, first seizure and frequency, as well as seizure severity using Racine's scale, were determined.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Palmitone, but not <jats:italic>A. diversifolia<\/jats:italic> extract, produced a delay in the latency to the SWS phase. In addition, both palmitone and extract decreased SWS duration and accumulated REM sleep phase. With regard to the seizures, both the extract and palmitone increased the latency to the onset of spikes and seizures, but also decreased the duration of penicillin\u2010induced seizures. This reduction in the EEG recordings was associated with an attenuation in the severity of behavioral seizures.<\/jats:p><jats:p> <jats:italic>Conclusions: A. diversifolia<\/jats:italic> and palmitone did not produce a sedative\u2010hypnotic effect although both of them were effective in reducing the severity of behavioral and EEG seizures induced by penicillin in rats, suggesting that the diminution in the paroxystic activity by <jats:italic>A. diversifolia<\/jats:italic> is likely produced by palmitone through GABAergic neurotransmission. This study justifies and reinforces the traditional use of this plant in epilepsy.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2006.00827.x","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T09:09:11Z","timestamp":1163668151000},"page":"1810-1817","source":"Crossref","is-referenced-by-count":31,"title":["Anticonvulsant Effect of <i>Annona diversifolia<\/i> Saff. and Palmitone on Penicillin\u2010induced Convulsive Activity. A Behavioral and EEG Study in Rats"],"prefix":"10.1111","volume":"47","author":[{"given":"Ma.","family":"Eva Gonz\u00e1lez\u2010Trujano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"L\u00f3pez\u2010Meraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Navarrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelfo","family":"Reyes\u2010Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01077.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(98)00051-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(91)90051-G"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90816-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90296-6"},{"key":"e_1_2_6_7_1","volume-title":"Surgical treatment of the epilepsies","author":"Engel J","year":"1993"},{"key":"e_1_2_6_8_1","first-page":"219","article-title":"Amygdaline penicillin focus replicates and modulates electrical amygdaloid kindling in the cat","volume":"43","author":"Fern\u00e1ndez\u2010Guardiola A","year":"1991","journal-title":"Proceedings of the Western Pharmacology Society"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(95)00037-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(89)90003-9"},{"key":"e_1_2_6_11_1","first-page":"627","article-title":"Curariform drug","volume":"619","author":"Gill RC","year":"1948","journal-title":"Brit"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(77)90198-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199812)12:8<600::AID-PTR363>3.0.CO;2-N"},{"issue":"7","key":"e_1_2_6_14_1","article-title":"Effect of single and repetitive administration of palmitone (a novel antiepileptic phytodrug) on benzodiazepine and delta opioid receptors binding in mice brain: an autoradiography study","volume":"41","author":"Gonz\u00e1lez\u2010Trujano ME","year":"2000","journal-title":"Epilepsia"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-11504"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-931598"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1191\/096032700667732543"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(81)90080-X"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.11.1381"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(95)00015-L"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03174-2"},{"issue":"5","key":"e_1_2_6_22_1","first-page":"7","article-title":"Intractable epilepsy in adults","author":"Leppik IE","year":"1992","journal-title":"Epilepsy Research"},{"key":"e_1_2_6_23_1","volume-title":"Contemporary diagnosis and management of the patient with epilepsy","author":"Leppik IE","year":"2001"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb02044.x"},{"key":"e_1_2_6_25_1","first-page":"119","article-title":"Localizing value of rapid eye movements sleep in temporal lobe epilepsy","volume":"44","author":"Malow BA","year":"2000","journal-title":"Sleep Medicine"},{"key":"e_1_2_6_26_1","first-page":"62","article-title":"Efecto de la estimulaci\u00f3n del nervio vago sobre la epilepsia focal amigdalina en la rata","volume":"27","author":"Mart\u00ednez A","year":"2004","journal-title":"Salud Mental"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/267720a0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(92)90009-4"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199705)11:3<243::AID-PTR66>3.0.CO;2-A"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00549-0"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(01)00191-7"},{"key":"e_1_2_6_32_1","volume-title":"The rat brain in stereotaxic coordinates","author":"Paxinos G","year":"2005"},{"issue":"1","key":"e_1_2_6_33_1","first-page":"25","article-title":"Effect of anticonvulsants on nocturnal sleep in epilepsy","volume":"54","author":"Placidi F","year":"2000","journal-title":"Neurology"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00411-9"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470200082007"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90177-0"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90037-1"},{"key":"e_1_2_6_38_1","first-page":"115","volume-title":"Clinical Pharmacokinetics: concepts and applications","author":"Rowland M","year":"1989"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.2_Part_1.290"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91453-4"},{"key":"e_1_2_6_41_1","first-page":"297","article-title":"The ketogenic diet: 1997","volume":"44","author":"Swink TD","year":"1997","journal-title":"Advances in Pediatric Infectious Diseases"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(95)00025-O"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80261-0"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1987-04.2004"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1528-1167.2006.00827.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1528-1167.2006.00827.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T03:50:56Z","timestamp":1697341856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1167.2006.00827.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1528-1167.2006.00827.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1528-1167.2006.00827.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}