{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:53:49Z","timestamp":1792047229706,"version":"4.4.0"},"reference-count":7,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T00:00:00Z","timestamp":1161820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> Unverricht\u2010Lundborg disease (ULD) is a progressive myoclonus epilepsy with tonic\u2013clonic seizures, action myoclonus, mild ataxia, without dementia. Persistence of invalidating action myoclonus is a major problem. Drugs like phenytoin can aggravate ULD. In this study, we retrospectively analyzed the effect of add\u2010on lamotrigine (LTG) in the five patients under our care who received LTG.<\/jats:p><jats:p> <jats:italic>Method:<\/jats:italic> Three men and two women, aged 20\u201350 years who had ULD confirmed by molecular biology, followed in two epilepsy centers, received add\u2010on LTG at 50\u2013300 mg\/d. All of them had valproate. The other drugs used in cotherapy were high\u2010dose piracetam, benzodiazepines phenobarbital, topiramate, and primidone. The assessment of LTG was based on detailed interview and clinical examination. Aggravation was diagnosed when myoclonic jerks (MJ) increased without irregular intake of medication, inappropriate lifestyle, encephalopathic or metabolic complications, or overdosage.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> In two patients, LTG exacerbated MJ in a dose\u2010dependent manner. In one patient, a delayed, severe exacerbation of myoclonus occurred that only ceased after LTG withdrawal and introduction of levetiracetam. These three patients had minor forms of ULD. In two patients with moderate to severe forms of ULD, LTG had no effect.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> Although symptoms may fluctuate in ULD, it was possible to pinpoint lack of improvement (2\/5), dose\u2010related exacerbation of myoclonus (2\/5), and putative late\u2010onset aggravation (1\/5) in five patients treated with adjunctive LTG. LTG does not appear to be a sensible treatment option in ULD.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2006.00829.x","type":"journal-article","created":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T15:55:01Z","timestamp":1161878101000},"page":"2083-2085","source":"Crossref","is-referenced-by-count":39,"title":["Lack of Efficacy and Potential Aggravation of Myoclonus with Lamotrigine in Unverricht\u2010Lundborg Disease"],"prefix":"10.1111","volume":"47","author":[{"given":"Pierre","family":"Genton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gelisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Crespel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1757"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000174517.21383.36"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90749-3"},{"key":"e_1_2_5_5_1","first-page":"441","volume-title":"Epileptic syndromes in infancy, childhood and adolescence","author":"Genton P","year":"2005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01413.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.56902.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00553.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1528-1167.2006.00829.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1528-1167.2006.00829.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T16:44:45Z","timestamp":1697129085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1167.2006.00829.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,26]]},"references-count":7,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1528-1167.2006.00829.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1528-1167.2006.00829.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,26]]}}}