{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:40:23Z","timestamp":1790192423058,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T00:00:00Z","timestamp":1162252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> Markers for epileptic seizures are rare and their use has not been established in the evaluation of seizures and febrile convulsions (FC). Brain\u2010type natriuretic peptide (BNP) is a natriuretic, diuretic, and vasodilator compound first discovered in the hypothalamus but mainly synthesized in the myocardium. The aim of this study was to assess whether epileptic seizures or FC are related to increased secretion of the N\u2010terminal fragment of BNP (NT\u2010proBNP).<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> Sixty\u2010five postictal children (43 boys, 22 girls) and 31 children with epilepsy (20 boys, 11 girls) after a seizure\u2010free period for at least 2 months serving as controls were enrolled. Postictal NT\u2010proBNP levels were analyzed and controlled 24\u201348 h thereafter.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Plasma concentration of NT\u2010proBNP was significantly higher 4 h postictal compared to 24\u201348 h postictal (p &lt; 0.001). Subgroup analysis revealed increased NT\u2010proBNP levels in children with tonic\u2013clonic seizures and FC compared to children with partial motor seizures (p &lt; 0.001), syncope (SYN; p &lt; 0.01), or control population (p &lt; 0.001).<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> Our results suggest that elevated plasma NT\u2010proBNP levels are not specific for cardiac dysfunction. Postictal measurement of plasma NT\u2010proBNP seems to be useful in discriminating different types of epilepsy, FC, and SYN in childhood.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2006.00837.x","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T16:06:13Z","timestamp":1162310773000},"page":"101-106","source":"Crossref","is-referenced-by-count":23,"title":["Brain\u2010type Natriuretic Peptide Secretion Following Febrile and Afebrile Seizures\u2014A New Marker in Childhood 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