{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:48:42Z","timestamp":1767905322613,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"s5","license":[{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Summary:\u2002<\/jats:bold>  <jats:italic>Purpose:<\/jats:italic> A limited number of cases of adult\u2010onset Rasmussen's encephalitis (A\u2010RE) have been reported, but the features of the syndrome are still unclear. The aim of this study was to verify the clinical features of A\u2010RE, and outline a noninvasive approach that may allow its early diagnosis and treatment.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic> Retrospective evaluation of extensive noninvasive work\u2010up of seven patients with A\u2010RE, including repeat clinical, neurophysiological, and neuroimaging investigations.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> The study identified two distinct patterns of disease presentation, one characterized by focal motor epilepsy (the \u201cepileptic\u201d phenotype), and the other by focal cortical myoclonus (the \u201cmyoclonic\u201d phenotype). Unilateral neurological deficits and brain atrophy were progressive in both phenotypes, but they were more prominent and were detected earlier in the \u201cepileptic\u201d phenotype.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> The anatomo\u2010electroclinical features of these patients allowed a noninvasive diagnosis of A\u2010RE and identification of two distinct disease phenotypes. Early noninvasive diagnosis can allow faster initiation of treatment.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2006.00876.x","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T07:30:03Z","timestamp":1166081403000},"page":"41-46","source":"Crossref","is-referenced-by-count":50,"title":["Adult\u2010Onset Rasmussen's Encephalitis: Anatomical\u2010Electrographic\u2010Clinical Features of 7 Italian Cases"],"prefix":"10.1111","volume":"47","author":[{"given":"Flavio","family":"Villani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pincherle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Antozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Chiapparini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Granata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Michelucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Rubboli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isa","family":"Simone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosella","family":"Bellomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Spreafico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200204000-00012"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf176"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh415"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10131"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.3.422"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.6.747"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.2.418"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.247"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00261-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540030035011"},{"key":"e_1_2_5_12_1","first-page":"7","volume-title":"Chronic encephalitis and epilepsy. Rasmussen's syndrome","author":"Oguni H","year":"1991"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.8.6.435"},{"key":"e_1_2_5_14_1","first-page":"79","volume-title":"Chronic encephalitis and epilepsy. Rasmussen's syndrome","author":"Robitaille Y","year":"1991"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1054\/jocn.1999.0173"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.2.248"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1528-1167.2006.00876.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1528-1167.2006.00876.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:49:34Z","timestamp":1695757774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1167.2006.00876.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":15,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1528-1167.2006.00876.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1528-1167.2006.00876.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}