{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:38:47Z","timestamp":1790044727851,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Purpose:\u2002<\/jats:bold>\n                    Fluorodeoxyglucose positron emission computed tomography (FDG\u2010PET) hypometabolism is important for surgical planning in patients with temporal lobe epilepsy (TLE), but its significance remains unclear in patients who do not have evidence of mesial temporal sclerosis (MTS) on magnetic resonance imaging (MRI). We examined surgical outcomes in a group of PET\u2010positive, MRI\u2010negative patients and compared them with those of patients with MTS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    We queried the Thomas Jefferson University Surgical Epilepsy Database for patients who underwent anterior temporal lobectomy (ATL) from 1991 to 2009 and who had unilateral temporal PET hypometabolism without an epileptogenic lesion on MRI (PET+\/MRI\u2212). We compared this group to the group of patients who underwent ATL and who had MTS on MRI. Patients with discordant ictal electroencephalography (EEG) were excluded. Surgical outcomes were compared using percentages of Engel class I outcomes at 2 and 5\u2003years as well as Kaplan\u2010Meier survival statistic, with time to seizure recurrence as survival time. A subgroup of PET+\/MRI\u2212 patients who underwent surgical implantation prior to resection was compared to PET+\/MRI\u2212 patients who went directly to resection without implantation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Key Findings:\u2002<\/jats:bold>\n                    There were 46 PET+\/MRI\u2212 patients (of whom 36 had 2\u2010year surgical outcome available) and 147 MTS patients. There was no difference between the two groups with regard to history of febrile convulsions, generalized tonic\u2013clonic seizures, interictal spikes, depression, or family history. Mean age at first seizure was higher in PET+\/MRI\u2212 patients (19\u2003\u00b1\u200313 vs.14\u2003\u00b1\u200313\u2003years, Mann\u2010Whitney test, p\u2003=\u20030.008) and disease duration was shorter (14\u2003\u00b1\u200310 vs. 22\u2003\u00b1\u200313\u2003years, student\u2019s\n                    <jats:italic>t<\/jats:italic>\n                    \u2010test, p\u2003=\u20030.0006). Class I surgical outcomes did not differ significantly between the PET+\/MRI\u2212 patients and the MTS group (2 and 5\u2003year outcomes were 76% and 75% for the PET+\/MRI\u2212 group, and 71% and 78% for the MTS group); neither did outcomes of the PET+\/MRI\u2212 patients who were implanted prior to resection versus those who went directly to surgery (implanted patients had 71% and 67% class I outcomes at 2 and 5\u2003years, whereas. nonimplanted patients had 77% and 78% class I outcomes, p\u2003=\u20030.66 and 0.28). Kaplan\u2010Meier survival statistics for both comparisons were nonsignificant at 5\u2003years. Dentate gyrus and hilar cell counts obtained from pathology for a sample of patients also did not differ between groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Significance:\u2002<\/jats:bold>\n                    PET\u2010positive, MRI\u2010negative TLE patients in our study had excellent surgical outcomes after ATL, very similar to those in patients with MTS, regardless of whether or not they undergo intracranial monitoring. These patients should be considered prime candidates for ATL, and intracranial monitoring is probably unnecessary in the absence of discordant data.\n                  <\/jats:p>","DOI":"10.1111\/j.1528-1167.2011.03359.x","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T15:29:32Z","timestamp":1324567772000},"page":"342-348","source":"Crossref","is-referenced-by-count":155,"title":["Surgical outcome in PET\u2010positive, MRI\u2010negative patients with temporal lobe epilepsy"],"prefix":"10.1111","volume":"53","author":[{"given":"Carla","family":"LoPinto\u2010Khoury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Skidmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maromi","family":"Nei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Sharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Mintzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02572.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.7.1358"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.283"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh257"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2007.12.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820203a9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199605000-00003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00734.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.9.1331"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.11.1670"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb01984.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540060022011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02720.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01080.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176055.45774.71"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540060046034"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.06.022"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.02.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1987.tb03650.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108023450501"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2007.04.001"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1528-1167.2011.03359.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1528-1167.2011.03359.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:10:12Z","timestamp":1698649812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1167.2011.03359.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,22]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1528-1167.2011.03359.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1528-1167.2011.03359.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,22]]}}}