{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:45:26Z","timestamp":1793749526212,"version":"4.6.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> To define the prevalence and risk factors for epilepsy in children in a rural district of Tanzania by conducting a community\u2010based case\u2013control study.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Children aged 6\u201314\u2003years with active epilepsy (at least two unprovoked seizures in the last 5\u2003years) were identified in a cross\u2010sectional survey in Tanzania. Cases were compared with age\u2010matched controls.<\/jats:p><jats:p><jats:bold>Key Findings:\u2002<\/jats:bold> Overall 112 children with epilepsy (CWE) were identified; the unadjusted prevalence of epilepsy was 2.91 per 1,000 (95% confidence interval [95% CI] 2.4\u20133.5). The main seizure types were focal motor with secondary generalization in 73 (65.2%) of 112 and generalized convulsive seizures in 19 (16.9%) of 112. Adverse perinatal events were present in 16 (14%) of 112 cases but in no controls. In multivariate analysis, epilepsy was associated with number of parents who were resident at home (odds ratio [OR] 6.2 for none vs. both resident, 95% CI 1.5\u201325.5), history of adverse perinatal events (OR 14.9, 95% CI 1.4\u2013151.3), family history of afebrile seizures (OR 5.7, 95% CI 1.0\u201327.5), and poor scholastic attainment (OR 8.6, 95% CI 4.0\u201318.4). Electroencephalography (EEG) and computed tomography (CT) scans were abnormal in 44 (44%) of 101 and 26 (29%) of 90 cases, respectively. Overall, 98 (88%) of 112 cases had focal features on assessment.<\/jats:p><jats:p><jats:bold>Significance:\u2002<\/jats:bold> In this study from sub\u2010Saharan Africa, CWE predominantly had focal features that support the suggestion that most epilepsy in this region has a symptomatic etiology. Adverse perinatal events were strongly associated with epilepsy. Genetic and social factors may also be important. Epilepsy may be preventable in a significant proportion of children with better antenatal and perinatal care.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2011.03395.x","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T19:53:31Z","timestamp":1328558011000},"page":"752-760","source":"Crossref","is-referenced-by-count":49,"title":["Epilepsy in Tanzanian children: Association with perinatal events and other risk factors"],"prefix":"10.1111","volume":"53","author":[{"given":"Kathryn J.","family":"Burton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Rogathe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitij","family":"Mankad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G. 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