{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:15:51Z","timestamp":1791148551921,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Purpose:\u2002<\/jats:bold> Focal seizures are thought to reflect simultaneous activation of a large population of neurons within a discrete region of pathologic brain. Resective surgery targeting this focus is an effective treatment in carefully selected patients, but not all. Although in vivo recordings of single\u2010neuron (i.e., \u201cunit\u201d) activity in patients with epilepsy have a long history, no studies have examined long\u2010term firing rates leading into seizures and the spatial relationship of unit activity with respect to the seizure\u2010onset zone.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Microelectrode arrays recorded action potentials from neurons in mesial temporal structures (often including contralateral mesial temporal structures) in seven patients with mesial temporal lobe epilepsy.<\/jats:p><jats:p><jats:bold>Key Findings:\u2002<\/jats:bold> Only 7.6% of microelectrode recordings showed increased firing rates before seizure onset and only 32.4% of microelectrodes showed any seizure\u2010related activity changes. Surprisingly, firing rates on the majority of microelectrodes (67.6%) did not change throughout the seizure, including some microelectrodes located within the seizure\u2010onset zone. Furthermore, changes in firing rate before and at seizure onset were observed on microelectrodes located outside the seizure\u2010onset zone and even in contralateral mesial temporal lobe. These early changes varied from seizure to seizure, demonstrating the heterogeneity of ensemble activity underlying the generation of focal seizures. Increased neuronal synchrony was primarily observed only following seizure onset.<\/jats:p><jats:p><jats:bold>Significance:\u2002<\/jats:bold> These results suggest that cellular correlates of seizure initiation and sustained ictal discharge in mesial temporal lobe epilepsy involve a small subset of the neurons within and outside the seizure\u2010onset zone. These results further suggest that the \u201cepileptic ensemble or network\u201d responsible for seizure generation are more complex and heterogeneous than previously thought and that future studies may find mechanistic insights and therapeutic treatments outside the clinical seizure\u2010onset zone.<\/jats:p>","DOI":"10.1111\/j.1528-1167.2012.03417.x","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T17:28:32Z","timestamp":1329845312000},"page":"807-816","source":"Crossref","is-referenced-by-count":89,"title":["Spatiotemporal neuronal correlates of seizure generation in focal epilepsy"],"prefix":"10.1111","volume":"53","author":[{"given":"Mark R.","family":"Bower","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Stead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredric B.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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