{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:46:57Z","timestamp":1791179217448,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T00:00:00Z","timestamp":1336003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Purpose:\u2002<\/jats:bold>\n                    To compare the effect of anxiety disorders, major depressive episodes (MDEs), and subsyndromic depressive episodes (SSDEs) on antiepileptic drug (AED)\u2013related adverse events (AEs) in persons with epilepsy (PWE).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    The study included 188 consecutive PWE from five U.S. outpatient epilepsy clinics, all of whom underwent structured interviews (SCID) to identify current and past mood disorders and other current Axis I psychiatric diagnoses according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM\u2010IV\u2010TR) criteria. A diagnosis of SSDE was made in patients with total Beck Depression Inventory\u2010II (BDI\u2010II) scores &gt;12 or the Centers of Epidemiologic Studies\u2010Depression (CES\u2010D) &gt; 16 (in\n                    <jats:italic>the absence<\/jats:italic>\n                    of any DSM diagnosis of mood disorder. The presence and severity of AEs was measured with the Adverse Event Profile (AEP).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Key Findings:\u2002<\/jats:bold>\n                    Compared to asymptomatic patients (n\u2003=\u2003103), the AEP scores of patients with SSDE (n\u2003=\u200326), MDE only (n\u2003=\u200310), anxiety disorders only (n\u2003=\u200321), or mixed MDE\/anxiety disorders (n\u2003=\u200328) were significantly higher, suggesting more severe AED\u2010related AEs. Univariate analyses revealed that having persistent seizures in the last 6\u2003months and taking antidepressants was associated with more severe AEs. Post hoc analyses, however, showed that these differences were accounted for by the presence of a depressive and\/or anxiety disorders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Significance:\u2002<\/jats:bold>\n                    Depressive and anxiety disorders worsen AED\u2010related AEs even when presenting as a subsyndromic type. These data suggest that the presence of psychiatric comorbidities must be considered in their interpretation, both in clinical practice and AED drug trials.\n                  <\/jats:p>","DOI":"10.1111\/j.1528-1167.2012.03488.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T09:57:58Z","timestamp":1336039078000},"page":"1104-1108","source":"Crossref","is-referenced-by-count":127,"title":["Depressive and anxiety disorders in epilepsy: Do they differ in their potential to worsen common antiepileptic drug\u2013related adverse events?"],"prefix":"10.1111","volume":"53","author":[{"given":"Andres M.","family":"Kanner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Gilliam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimford J.","family":"Meador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,3]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Diagnostic and statistical manual of mental disorders IV\u2010TR","author":"American Psychiatric Association","year":"2000"},{"issue":"7","key":"e_1_2_6_3_1","first-page":"80","article-title":"Initial development, reliability, and validity of a patient\u2010based adverse event scale","volume":"35","author":"Baker GA","year":"1994","journal-title":"Epilepsia"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck AT","year":"1987","journal-title":"Arch Gen Psychiatry"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2003.07.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000138430.11829.61"},{"key":"e_1_2_6_7_1","volume-title":"Structured clinical interview for DSM IV Axis I disorders","author":"First MB","year":"1995"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.1.23"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70415-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318207b073"},{"issue":"20","key":"e_1_2_6_12_1","first-page":"22","article-title":"The Mini International Neuropsychiatric Interview (MINI): the development and validation of structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan BV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01222.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112455"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1528-1167.2012.03488.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1528-1167.2012.03488.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:35:37Z","timestamp":1698654937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1167.2012.03488.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,3]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1528-1167.2012.03488.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1528-1167.2012.03488.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,3]]}}}