{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:04:12Z","timestamp":1758632652663},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T00:00:00Z","timestamp":1156377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Abstract\u2003<\/jats:bold> Intoxication by <jats:italic>Karwinskia humboldtiana<\/jats:italic> (buckthorn) fruit presents a neurological picture similar to that of Guillain\u2010Barr\u00e9 syndrome. In this report, we describe an experimental animal model of peripheral neuropathy induced by buckthorn fruit. Four groups of Wistar rats received one oral dose of 1.5 g\/kg followed by oral doses of 0.5 g\/kg at days 3, 7, 10, and 14 of dried and ground buckthorn fruit in aqueous suspension. Rats were sacrificed at 24, 48, 58, and 112 days after initial dose. Treated animals developed progressive paralysis through 58 days, then completely recovered by 112 days. Sciatic nerves showed segmental demyelination and cellular infiltrates until 58 days after exposure and then remyelinating changes at 112 days. This experimental model for peripheral neuropathy is reproducible and easy to handle. Its manipulation is relatively innocuous and allows us to study reversible peripheral nerve damage. This model can be developed in other animal species and may be useful to test new therapies for peripheral neuropathy.<\/jats:p>","DOI":"10.1111\/j.1529-8027.2006.00096.x","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T22:37:10Z","timestamp":1156891030000},"page":"253-261","source":"Crossref","is-referenced-by-count":13,"title":["An experimental model of peripheral neuropathy induced in rats by <i>Karwinskia humboldtiana<\/i> (buckthorn) fruit"],"prefix":"10.1111","volume":"11","author":[{"given":"Martha E.","family":"Salazar\u2010Leal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Sepulveda\u2010Saavedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor J.","family":"Romero\u2010Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo M.","family":"Becerra\u2010Verdin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor A.","family":"Tamez\u2010Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector R.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Pi\u00f1eyro\u2010Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"Bermudez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"105","article-title":"Intoxicaci\u00f3n por Karwinskia johnstonii Fern\u00e1ndez: estudio de 12 pacientes","volume":"51","author":"Arellano E","year":"1994","journal-title":"Bol Med Hosp Infant Mex"},{"key":"e_1_2_6_3_1","first-page":"501","article-title":"Peroxisomicine A\u20101 induces TNF\u03b1 secretion and PMN infiltration in lung microvascular bed of albino mice (CD\u20101)","volume":"4","author":"Ballesteros R","year":"1998","journal-title":"Electron microscopy ICEMI4 symposium RR"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(86)90135-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(92)90527-C"},{"key":"e_1_2_6_6_1","first-page":"100","article-title":"Familial poisoning with Karwinskia humboldtiana","volume":"131","author":"Bermudez de Rocha MV","year":"1995","journal-title":"Gac Med Mex"},{"key":"e_1_2_6_7_1","first-page":"241","article-title":"Fatal poisoning caused by tullidora (Karwinskia humboldtiana) Report of a case","volume":"114","author":"Bustamante\u2010Sarabia J","year":"1978","journal-title":"Gac Med Mex"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00850a037"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"Nombres comunes, usos y distribucion geografica del genero Karwinskia (Rhamnaceae) en Mexico. 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