{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:25:16Z","timestamp":1696508716518},"reference-count":11,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Twenty\u2010four patients, all of whom were exposed to aerosolized porcine brain tissue through work\u2010place environment (abattoir), developed a syndrome of immune\u2010mediated polyradiculoneuropathy; three also had central nervous system manifestations (transverse myelitis, meningoencephalitis, and aseptic meningitis). Patients had characteristic electrophysiological findings of very distal and proximal conduction slowing (prolonged distal and F\u2010wave latencies, regions where the blood\u2010nerve barrier is the most permeable) and all patients' serum contained a novel IgG immunofluorescence pattern. Nerve pathology, when available, showed mild changes of segmental demyelination, axonal degeneration, and inflammatory changes. Patients had meaningful improvement of symptoms and electrophysiologic findings with immune therapy and with removal of exposure to aerosolized brain tissue. We postulate that this outbreak is an auto\u2010immune polyradiculoneuropathy triggered by occupational exposure to multiple aerosolized porcine neural tissue antigens that result in neural damage where the blood\u2010nerve barrier is the least robust.<\/jats:p>","DOI":"10.1111\/j.1529-8027.2011.00303.x","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T20:40:39Z","timestamp":1308775239000},"page":"34-37","source":"Crossref","is-referenced-by-count":6,"title":["Auto\u2010immune polyradiculoneuropathy and a novel IgG biomarker in workers exposed to aerosolized porcine brain"],"prefix":"10.1111","volume":"16","author":[{"given":"Jennifer A.","family":"Tracy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. James B.","family":"Dyck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,22]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"63","article-title":"Etude sur la rage paralytique chez l\u2019homme.","volume":"1","author":"Gamaleia N","year":"1887","journal-title":"Ann Inst Pasteur"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(99)01639-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(84)90136-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198702123160703"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.4.550"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009782"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.85.1.117"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.12_suppl_6.S7"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70296-0"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.102.2.213"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200006)47:6<765::AID-ANA9>3.0.CO;2-8"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1529-8027.2011.00303.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1529-8027.2011.00303.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T03:51:32Z","timestamp":1694922692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1529-8027.2011.00303.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":11,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1529-8027.2011.00303.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1529-8027.2011.00303.x","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}