{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T22:47:40Z","timestamp":1771454860220,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>In the quest for susceptibility factors of inflammatory neuropathies, many genes implicated in the pathogenesis of autoimmune diseases have been investigated with negative or conflicting results. We studied, with a gene candidate approach, the <jats:italic>CD1<\/jats:italic> system specialized in capturing and presenting glycolipids to antigen\u2010specific T cells, and the <jats:italic>SH2D2A<\/jats:italic> gene encoding for a T\u2010cell\u2010specific adapter protein implicated in control of early T\u2010cell activation. In Guillain\u2013Barr\u00e9 syndrome, an initially positive association study with polymorphism of <jats:italic>CD1A<\/jats:italic> and <jats:italic>CD1E<\/jats:italic> genes was not confirmed. In chronic inflammatory demyelinating polyneuropathy, we did not find an association with <jats:italic>CD1<\/jats:italic> genes, but we found an association with a homozygous genotype for a low repeat number of tandem GA in the <jats:italic>SH2D2A<\/jats:italic> gene. This genotype could result in defective control and elimination of autoreactive T cells. All the studies were performed on relatively small size populations. Confirmation in larger sized studies is required both for <jats:italic>CD1<\/jats:italic> and <jats:italic>SH2D2A<\/jats:italic> genes. Considering the relative rarity of patients with inflammatory neuropathies, this can only be accomplished by international collaboration.<\/jats:p>","DOI":"10.1111\/j.1529-8027.2011.00307.x","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T20:40:39Z","timestamp":1308775239000},"page":"48-51","source":"Crossref","is-referenced-by-count":23,"title":["Polymorphism of <i>CD1<\/i> and <i>SH2D2A<\/i> genes in inflammatory neuropathies"],"prefix":"10.1111","volume":"16","author":[{"given":"Antonino","family":"Uncini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Notturno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Pace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina 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