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We review the axonal Charcot\u2010Marie\u2010Tooth subtypes with onset in infancy, spinal muscular atrophy, and related syndromes of early infancy, giant axonal neuropathy, infantile neuroaxonal dystrophy, hereditary motor and sensory neuropathy with agenesis of the corpus callosum, early\u2010onset neuropathies associated with mitochondrial disorders, and other less well\u2010delineated clinical entities. 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