{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:54:12Z","timestamp":1770778452892,"version":"3.50.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In hereditary neuropathy with liability to pressure palsies (<jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content>), the increase in distal motor latencies (<jats:styled-content style=\"fixed-case\">DMLs<\/jats:styled-content>) is often out of proportion to the slowing of conduction velocities, but the pathophysiological mechanism is still unclear. We used a combined electrophysiological and ultrasonographic (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>) approach to provide insight into this issue. Twelve <jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content> subjects underwent extensive electrophysiological studies and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> measurements of the cross\u2010sectional area (<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>) of several peripheral nerves. <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> nerve enlargement was only observed in the carpal tunnel, Guyon's canal, the elbow and the fibular head. We did not observe <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> abnormalities at sites where nerve entrapment is uncommon. An increase in <jats:styled-content style=\"fixed-case\">DMLs<\/jats:styled-content> was observed regardless of <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> nerve enlargement. The increased nerve <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content> only in common sites of entrapment likely reflected the well\u2010documented nerve vulnerability to mechanical stress in <jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content>. No morphometric changes were seen in the distal nerve segments where compression\/entrapment is unlikely, despite the fact that the <jats:styled-content style=\"fixed-case\">DMLs<\/jats:styled-content> were increased. These data suggest that factors other than mechanical stress are responsible for the distal slowing of action potential propagation. We speculate that a mixture of mechanical insults and an axon\u2010initiated process in the distal nerves underlies the distal slowing and\/or conduction failure in <jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1529-8027.2012.00437.x","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T05:33:56Z","timestamp":1356154436000},"page":"391-398","source":"Crossref","is-referenced-by-count":25,"title":["Sonographic and electrodiagnostic features of\u00a0hereditary neuropathy with liability to pressure palsies"],"prefix":"10.1111","volume":"17","author":[{"given":"Federica","family":"Ginanneschi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Filippou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Immunology University of Siena  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Carluccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Adinolfi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Immunology University of Siena  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Frediani","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Immunology University of Siena  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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