{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:49:52Z","timestamp":1788893392182,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":9892,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p>Ethanol has been demonstrated to cause aberrations in lipoprotein metabolism, cholesterol synthesis, biliary secretion, and bile acid synthesis. Although there is interdependency of cholesterol and bile acid metabolism, a role of ethanoMnduced lipid abnormalities in altering bile acid synthesis has not been found. The direct effects of ethanol administration on bile acid metabolism have been studied in animals and vary with the experimental design. Acutely, ethanol causes decreased bile acid secretion and synthesis, but other effects are less well defined. Chronic ethanol use in man may result in cirrhosis, a condition in which abnormalities of bile acid metabolism have been described in detail. Cholic acid synthesis and pool size are markedly depressed In advanced cirrhosis. Che\u2010nodeoxycholic acid synthesis is effected less than cholic acid synthesis, probably because 12a\u2010hydrox\u2010ylase activity is markedly depressed in cirrhosis, although other steps may also be influenced such as 7a\u2010hydroxylation of cholesterol or availability of cholesterol precursor. The deoxycholic acid pool is depressed probably because of changes in fecal flora. Despite the decrease in total bile acid pool, lithogenicity of bile is not increased in cirrhotic patients because of a concomitant decline in cholesterol and phospholipid secretion. Changes in hepatic blood flow and hepatic extraction cause an increase in plasma bile acid levels which may have clinical relevance.<\/jats:p>","DOI":"10.1111\/j.1530-0277.1981.tb04871.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T12:07:50Z","timestamp":1282133270000},"page":"92-100","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Acute and Chronic Ethanol Intake on Bile Acid Metabolism"],"prefix":"10.1111","volume":"5","author":[{"given":"Paul","family":"Monroe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. 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