{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:37:50Z","timestamp":1774867070101,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,12]],"date-time":"2006-04-12T00:00:00Z","timestamp":1144800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Long\u2010term ethanol consumption in aging rats results in degeneration and regression of the Purkinje neuron (PN) dendritic arbor. One marked ethanol\u2010related change in Purkinje dendrite ultrastructure is dilation of the smooth endoplasmic reticulum (SER) within PN dendritic shafts. The purpose of this study was to determine a time course for ethanol\u2010related dendritic regression in PN dendritic shafts and spines.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> One\u2010hundred eighty aging, male Fischer 344 rats were used. Four durations of treatment (5, 10, 20, and 40 weeks) and 3 dietary treatment groups (60 rats\/treatment group) were studied. Ethanol\u2010fed rats received a liquid ethanol diet (35% of dietary calories from ethanol). Pair\u2010fed rats received an isocaloric liquid control diet and chow\u2010fed rats received rat chow and water ad libitum. After each duration of treatment, 45 rats (15\/treatment) were euthanized and 2 posterior cerebellar lobules\/rat were viewed with electron microscopy and photographed. Diameters of SER profiles within PN shafts and spines were measured with image analysis.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Ethanol\u2010related SER dilation in dendritic shafts occurred following 40 weeks of treatment. Ethanol\u2010related SER dilation was not detected in PN dendritic spines.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> These results confirm that ethanol\u2010related dilation of SER profiles in PN dendritic shafts occurs following the same duration of treatment as the dendritic regression previously reported in other studies. Degenerating bodies that may be linked to dendritic regression were also identified in PN dendrites.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2006.00103.x","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T21:24:50Z","timestamp":1145654690000},"page":"883-891","source":"Crossref","is-referenced-by-count":12,"title":["Ethanol\u2010Related Smooth Endoplasmic Reticulum Dilation in Purkinje Dendrites of Aging Rats"],"prefix":"10.1111","volume":"30","author":[{"given":"Cynthia A.","family":"Dlugos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(03)00141-6"},{"key":"e_1_2_6_3_1","first-page":"1077","article-title":"The neuronal endoplasmic reticulum","volume":"31","author":"Broadwell RD","year":"1983","journal-title":"its cytochemistry and contribution to the endomembrane system"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589803500105"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007015721754"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01588-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.4.1151"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Analyses of smooth endoplasmic reticulum of cerebellar parallel fibers in aging, ethanol\u2010fed rats","volume":"35","author":"Dlugos CA","year":"2005","journal-title":"Alcoholism"},{"issue":"29","key":"e_1_2_6_9_1","first-page":"122A","article-title":"Purkinje neuron number is unaltered by chronic ethanol treatment in aging rats","author":"Dlugos CA","year":"2005","journal-title":"Alcohol Clin Exp Res 29"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.alcalc.a008250"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(99)00064-6"},{"key":"e_1_2_6_12_1","first-page":"211","volume-title":"Neurobiology of Aging","author":"Feldman ML","year":"1976"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90411-T"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1977.tb00062.x"},{"key":"e_1_2_6_15_1","first-page":"4455","article-title":"Dendritic spines of rat cerebellar Purkinje cells","volume":"8","author":"Harris KM","year":"1988","journal-title":"serial electron microscopy with reference to their biophysical characteristics"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(91)90012-P"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1017\/S0317167100048502","article-title":"Structural and molecular compartmentation in the cerebellum","volume":"20","author":"Hawkes T","year":"1993","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_6_18_1","first-page":"267a","article-title":"The endoplasmic reticulum of neurons as a calcium sequestering and releasing system","volume":"15","author":"Henkart M","year":"1975","journal-title":"morphological evidence"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0835746100"},{"key":"e_1_2_6_20_1","first-page":"11","article-title":"Age\u2010related changes in the dendrites in the cat","volume":"81","author":"Iontov AS","year":"1981","journal-title":"Arkh Anat Gistol Embriol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900970204"},{"key":"e_1_2_6_22_1","first-page":"51","article-title":"Ethanol\u2010induced changes in Purkinje cells of the rat cerebellum 1. 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