{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T05:06:22Z","timestamp":1794632782602,"version":"4.9.1"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Sleep disturbances are frequently encountered in alcohol\u2010dependent patients. Drugs improving sleep during abstinence from alcohol may play an important role in the recovery process.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>In the present study, the effects of acamprosate, a drug successfully used in maintaining abstinence following alcohol withdrawal, were assessed by polysomnographic recordings. A parallel double\u2010blind placebo\u2010controlled study was conducted in 24 male DSM\u2010IV alcohol\u2010dependent subjects aged 35.9\u00b11.2 years. Treatments (2 tablets of 333 mg acamprosate vs placebo t.i.d.) were initiated 8 days before alcohol withdrawal and continued during the 15 days following alcohol withdrawal. Polysomnographic assessments were recorded during acute withdrawal (the first 2 nights following withdrawal) and during postwithdrawal abstinence (the last 2 nights of the trial).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Results show that, compared with placebo, acamprosate decreased wake time after sleep onset and increased stage 3 and REM sleep latency (all treatment effects with a<jats:italic>p<\/jats:italic>&lt;0.05 significance). Withdrawal effects themselves were also demonstrated as sleep efficiency (<jats:italic>p<\/jats:italic>&lt;0.01) and total sleep time (<jats:italic>p<\/jats:italic>&lt;0.05) were lower in abstinence nights versus withdrawal nights, whereas no significant treatment \u00d7 withdrawal effect could be evidenced. Acamprosate was well tolerated during the entire course of the study.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold>The present study shows that acamprosate ameliorates both sleep continuity and sleep architecture parameters classically described as disturbed in alcohol\u2010dependent patients. From a clinical perspective, it suggests that an 8\u2010day acamprosate prewithdrawal treatment is well tolerated and can attenuate the sleep disturbances engendered by alcohol withdrawal in alcohol\u2010dependent subjects.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2006.00180.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T10:25:07Z","timestamp":1155551107000},"page":"1492-1499","source":"Crossref","is-referenced-by-count":54,"title":["Effects of Acamprosate on Sleep During Alcohol Withdrawal: A Double\u2010Blind Placebo\u2010Controlled Polysomnographic Study in Alcohol\u2010Dependent Subjects"],"prefix":"10.1111","volume":"30","author":[{"given":"Staner","family":"Luc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boeijinga","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danel","family":"Thierry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gendre","family":"Isabelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzet","family":"Muriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landron","family":"Fr\u00e9d\u00e9ric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luthringer","family":"R\u00e9my","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1973.01750310116019"},{"key":"e_1_2_5_3_1","first-page":"810","article-title":"Mechanism of action of acamprosate","volume":"22","author":"Al Qatari M","year":"1998","journal-title":"Part II. 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