{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:01:26Z","timestamp":1787014886278,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T00:00:00Z","timestamp":1159488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    While alcohol consumption is known to increase the incidence and severity of infections, the impact of alcohol consumption on human immunodeficiency virus (HIV) disease progression has been difficult to assess. Therefore, we examined the effect of ethanol on simian immunodeficiency virus (SIV) disease progression in a well\u2010defined model utilizing rhesus macaques.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Alcohol was administered for 5 hours via an indwelling intragastric catheter to achieve an alcohol concentration of 50 to 60 mM for 4 consecutive days per week for the duration of the study. Control animals received isocaloric sucrose. After 3 months, animals were inoculated intravenously with 10,000 times the ID\n                    <jats:sub>50<\/jats:sub>\n                    of SIV\n                    <jats:sub>DeltaB670<\/jats:sub>\n                    and followed to end\u2010stage disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Plasma SIV ribonucleic acid (RNA) was higher in alcohol\u2010consuming animals compared with sucrose\u2010treated animals during the early asymptomatic stage of disease but not at later time points. This increase in viral set point was associated with more rapid progression to end\u2010stage disease in macaques administered alcohol (median=374 days) compared with sucrose (median=900 days). The decline in blood CD4+ cells was similar in both groups of animals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This study indicates that frequent episodes of alcohol intoxication in SIV+ macaques increase viral set point in association with more rapid development of end\u2010stage disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1530-0277.2006.00211.x","type":"journal-article","created":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T16:31:22Z","timestamp":1159547482000},"page":"1781-1790","source":"Crossref","is-referenced-by-count":58,"title":["Chronic Binge Ethanol Consumption Accelerates Progression of Simian Immunodeficiency Virus Disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Gregory J.","family":"Bagby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette E.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Didier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00795.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000057947.57330.BE"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00244-2"},{"key":"e_1_2_6_5_1","first-page":"76","article-title":"Alcohol's role in gastrointestinal disorders","volume":"21","author":"Bode C","year":"1997","journal-title":"Alcohol Health Res World"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(05)80306-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199609000-00004"},{"key":"e_1_2_6_8_1","first-page":"107","article-title":"A TH1","volume":"14","author":"Clerici M","year":"1993","journal-title":"TH2 switch is a critical step in the etiology of HIV infection"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115713"},{"key":"e_1_2_6_10_1","first-page":"213","volume-title":"Alcohol, Drugs of Abuse, and Immune Functions","author":"Cohen DA","year":"1995"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.122.1.56"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.110104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00119-N"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.2.337"},{"key":"e_1_2_6_15_1","first-page":"277","article-title":"Quantitative measure of muscle strength and size in chronic alcoholism","volume":"15","author":"Freilich R","year":"1996","journal-title":"an early indication of tissue damage"},{"key":"e_1_2_6_16_1","first-page":"49","article-title":"Social and behavioural factors associated with HIV seroconversion in homosexual men attending a central London STD clinic","volume":"12","author":"Gilbart VL","year":"2000","journal-title":"a feasibility study"},{"key":"e_1_2_6_17_1","first-page":"235","article-title":"Alcohol abuse and acute lung injury","volume":"53","author":"Guidot DM","year":"2005","journal-title":"epidemiology and pathophysiology of a recently recognized association"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00088.2003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011614"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2003.64.564"},{"key":"e_1_2_6_21_1","first-page":"1060","article-title":"HIV in the United States at the turn of the century","volume":"91","author":"Karon JM","year":"2001","journal-title":"an epidemic in transition"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1001\/jama.1989.03420230078030","article-title":"No evidence for a role of alcohol or other psychoactive drugs in accelerating immunodeficiency in HIV\u20101\u2010positive individuals. A report from the Multicenter AIDS Cohort Study","volume":"261","author":"Kaslow RA","year":"1989","journal-title":"JAMA"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199709000-00005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9902099"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001469"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/08892220260139495"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1544"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000164517.01293.84"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02599920"},{"key":"e_1_2_6_30_1","first-page":"212","article-title":"The acute and chronic effects of alcohol on the human immune system","volume":"141","author":"Lundy J","year":"1975","journal-title":"Surg Gyn Obstet"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380110080031"},{"key":"e_1_2_6_32_1","first-page":"291","article-title":"Alcohol and infection","volume":"17","author":"MacGregor RR","year":"1997","journal-title":"Curr Clin Top Infect Dis"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.4.825"},{"key":"e_1_2_6_34_1","first-page":"33","article-title":"HIV treatment in drug abusers","volume":"8","author":"Miguez MJ","year":"2003","journal-title":"impact of alcohol use"},{"key":"e_1_2_6_35_1","first-page":"481","article-title":"Peripheral neuropathy with nucleoside antiretrovirals","volume":"19","author":"Moyle GJ","year":"1998","journal-title":"risk factors, incidence and management"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(94)90048-5"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5320.1857"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03645.x"},{"key":"e_1_2_6_39_1","first-page":"1031","article-title":"Alcoholism and AIDS","volume":"26","author":"Pfefferbaum A","year":"2002","journal-title":"magnetic resonance imaging approaches for detecting interactive neuropathology"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199609000-00019"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2005.21.863"},{"key":"e_1_2_6_42_1","first-page":"862","article-title":"Alcohol consumption and HIV disease progressio","volume":"27","author":"Samet JH","year":"2003","journal-title":"are they related?"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90301-8"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-10-2441"},{"key":"e_1_2_6_45_1","first-page":"3","article-title":"HIV\u2010positive gay and bisexual men","volume":"15","author":"Semple SJ","year":"2003","journal-title":"predictors of unsafe sex"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1086\/315728"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2004.65.434"},{"key":"e_1_2_6_48_1","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1128\/JVI.73.6.4829-4839.1999","article-title":"Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection","volume":"73","author":"Staprans SI","year":"1999","journal-title":"J Virol"},{"key":"e_1_2_6_49_1","first-page":"1139","article-title":"Prevalence of alcohol problems among selected AIDS risk groups","volume":"88","author":"Stinson FS","year":"1993","journal-title":"United States, 1988"},{"key":"e_1_2_6_50_1","volume-title":"Drinking in the U.S.: Main findings from the National Longitudinal Alcohol Epidemiological Survey. U.S. Alcohol Epidemiologic Data Reference Manual NIH Publication No 99\u20103519","author":"Stinson FS","year":"1997"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1998.14.183"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/34.6.830"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5362.427"},{"key":"e_1_2_6_54_1","first-page":"626","article-title":"The mucosal immune system","volume":"22","author":"Veazey RS","year":"2001","journal-title":"primary target for HIV infection and AIDS"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00872.x"},{"key":"e_1_2_6_56_1","first-page":"284","article-title":"Plasma viremia in macaques infected with simian immunodeficiency virus","volume":"71","author":"Watson A","year":"1997","journal-title":"plasma viral load early in infection predicts survival"},{"key":"e_1_2_6_57_1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/oxfordjournals.aje.a116358","article-title":"Alcohol measuring scales may influence conclusions about the role of alcohol in human immunodeficiency virus (HIV) risk and progression to acquired immunodeficiency syndrome (AIDS)","volume":"135","author":"Westerberg VS","year":"1992","journal-title":"Am J Epidemiol"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00748-1"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02492.x"},{"key":"e_1_2_6_60_1","first-page":"107","article-title":"Iron\u2010dependent activation of NF\u2010kappaB in Kupffer cells","volume":"30","author":"Xiong S","year":"2003","journal-title":"a priming mechanism for alcoholic liver disease"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.1.163"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.2741\/A842"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117924"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1530-0277.2006.00211.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1530-0277.2006.00211.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:31:16Z","timestamp":1697070676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1530-0277.2006.00211.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,29]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1530-0277.2006.00211.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1530-0277.2006.00211.x","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,29]]}}}