{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:47:27Z","timestamp":1789886847790,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T00:00:00Z","timestamp":1165536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Dysfunctional hyperarousal is suspected to be a neurophysiological determinant of relapse in abstinent alcohol\u2010dependent patients. In the present study, we used spectral power analysis of the sleep electroencephalographic (EEG) to quantify brain activity during sleep in patients during subacute withdrawal as well as in control subjects. Our hypothesis was that the subgroup of patients who relapsed within the 3 months to follow\u2010up would exhibit\u2010increased dysfunctional arousal manifested by higher\u2010frequency (<jats:italic>\u03b2<\/jats:italic>) EEG power during sleep.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Twenty\u2010six alcohol\u2010dependent in\u2010patients were examined with polysomnography over 2 nights 2 to 3 weeks after withdrawal. At the 3\u2010month clinical follow\u2010up assessment, 12 of them had relapsed and 14 abstained. The control group consisted of 23 healthy subjects similar to the patients with alcohol dependence in age and gender distribution. Spectral sleep EEG analysis was performed on both nights (adaptation and baseline) of all subjects. Logarithmic artifact\u2010controlled spectral band power of sleep stage 2 and rapid eye movement (REM) sleep was analyzed for Group, Gender, and Age effects using multiple analyses of covariance. Three groups were compared with the Group factor: relapsers, abstainers, and controls.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Generally, both Group and Age effects were significant for the second, baseline night for the visually scored sleep parameters, while spectral EEG parameters showed significant differences in the adaptation night. In the adaptation night, a significant enhancement in the <jats:italic>\u03b2<\/jats:italic>2 band (24\u201332 Hz) was seen in REM sleep in relapsers relative to both abstainers and controls.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The <jats:italic>\u03b2<\/jats:italic>2 increase could be interpreted as a sign of dysfunctional arousal during REM sleep \u201cunmasked\u201d by the additional stressor of sleep environment adaptation. Its determinants are likely to be both premorbid and drinking history related.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2006.00260.x","type":"journal-article","created":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T09:26:14Z","timestamp":1165569974000},"page":"19-27","source":"Crossref","is-referenced-by-count":46,"title":["Sleep Electroencephalographic Spectral Power After Withdrawal from Alcohol in Alcohol\u2010Dependent 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