{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:15:36Z","timestamp":1794046536668,"version":"4.8.0"},"reference-count":15,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T00:00:00Z","timestamp":1172534400000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Nonalcoholic fatty liver disease (NAFLD) includes both nonalcoholic fatty liver (FL) and nonalcoholic steatohepatitis (NASH). It has previously been reported that alcoholic hepatitis, which shows morphological findings similar to that of NASH, leads to the onset of endotoxinemia and to an increase in the production of tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>(TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and\/or interleukin\u20101 (IL\u20101) from macrophages. Tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>and IL\u20101 induce strong expression of intercellular adhesion molecule\u20101 (ICAM\u20101) of the cell membranes of hepatocytes and\/or sinusoidal endothelial cells, resulting in increased serum ICAM\u20101 levels in our previous study. In this study, we clarified the significance of serum ICAM\u20101 levels in patients with NAFLD, and especially in NASH.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>Thirty\u2010three obese patients of NAFLD (FL:<jats:italic>n<\/jats:italic>=14, NASH:<jats:italic>n<\/jats:italic>=19) with no habit of drinking, 20 cases of alcoholic liver diseases (alcoholic hepatitis; ASH:<jats:italic>n<\/jats:italic>=10, alcoholic hepatic fibrosis; HF:<jats:italic>n<\/jats:italic>=10), and 10 healthy individuals were studied. Serum ICAM\u20101 concentrations were analyzed by enzyme\u2010linked immunoassay in patients with NAFLD and alcoholic liver diseases. Potential factors were assessed for increase in serum ICAM\u20101 and a diagnostic tool for NASH including ICAM\u20101 levels, C\u2010reactive protein (CRP), white blood cell count, aspartate aminotransferase, alanine aminotransferase,<jats:italic>\u03b3<\/jats:italic>\u2010gluatmyl transferase, total cholesterol, triglyceride, type\u2010IV collagen, body mass index, homeostasis model assessment (HOMA\u2010IR), and existence of high blood pressure.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>The serum ICAM\u20101 level was significantly higher in the patients with NASH than in the patients with FL, and in the normal subjects. The serum ICAM\u20101 level was also significantly higher in the patients with ASH. The serum ICAM\u20101 level in the patients with ASH was remarkably high compared with that of the patients with NASH. No significant difference in serum ICAM\u20101 levels was found between the patients with NASH and those with HF. The serum ICAM\u20101 level was significantly higher in patients with high blood pressure than in those without high blood pressure in NAFLD. A multivariate analysis using multiple logistic regression showed that high blood pressure and GGTP were the significant factors contributing to high serum ICAM\u20101 levels, while highly sensitive CRP and ICAM\u20101 were the significant factors for the diagnosis of NASH.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold>The serum ICAM\u20101 concentration is increased in patients with NASH. The serum level of ICAM\u20101 in patients with NAFLD may be a useful marker for the diagnosis of NASH.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2006.00292.x","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T16:34:23Z","timestamp":1172594063000},"source":"Crossref","is-referenced-by-count":31,"title":["Serum Intercellular Adhesion Molecule\u20101 in Patients With Nonalcoholic Steatohepatitis: Comparison With Alcoholic Hepatitis"],"prefix":"10.1111","volume":"31","author":[{"given":"Shuji","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyokazu","family":"Yukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Uetake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70368-4"},{"key":"e_1_2_6_3_1","first-page":"2467","article-title":"Nonalcoholic steatohepatitis","volume":"94","author":"Brunt EM","year":"1999","journal-title":"a proposal for grading and staging the histological lesions"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.2.268"},{"key":"e_1_2_6_5_1","first-page":"245","article-title":"Induction by IL\u20101 and interferon\u2010\u03b3","volume":"137","author":"Dustin LM","year":"1986","journal-title":"tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70211-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(85)90049-6"},{"key":"e_1_2_6_8_1","first-page":"496","article-title":"NAD(P) H Oxidase","volume":"86","author":"Griendlling KK","year":"2000","journal-title":"role in cardiovascular biology and disease"},{"key":"e_1_2_6_9_1","first-page":"661","article-title":"Performance assessment of the CRP high sensitivity measurement method using the BNII nepherometer\u2014application as a prognosis factor for patients with arteria coronaria","volume":"25","author":"Kuwa K","year":"2000","journal-title":"Japan J Clin Lab Autom"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50048"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0025-6196(24)00530-5","article-title":"Nonalcoholic steatohepatitis. 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