{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:30:05Z","timestamp":1762781405778},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T00:00:00Z","timestamp":1168387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> There has been considerable focus on the adolescent stage of development in the study of alcohol use and the etiology of alcohol\u2010related problems. Because adolescence is a process of dynamic change rather than a discrete or static stage of development, it is important to consider ontogenetic changes in the response to ethanol within the adolescent time period. In rodents, levels of ethanol\u2010induced motor impairment have been shown to increase from early to late adolescence. This study investigated associations between behavior following acute ethanol administration and age, rearing condition (mother\u2010reared vs nursery\u2010reared), and serotonin transporter (rh5\u2010HTTLPR) genotype in a sample of alcohol\u2010na\u00efve adolescent rhesus macaques.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Rhesus macaques (<jats:italic>n<\/jats:italic>=97; 41 males, 56 females), ranging in age from 28 to 48 months, were administered intravenous (IV) doses of ethanol (2.2 g\/kg for males, 2.0 g\/kg for females) twice in 2 separate testing sessions. A saline\/ethanol group (<jats:italic>n<\/jats:italic>=16; 8 males, 6 females) was administered saline in 1 testing session and ethanol in the second session. Following each IV injection, subjects underwent a 30\u2010minute general motor behavioral assessment. Behavior in the saline\/ethanol group was compared between the saline and ethanol\u2010testing sessions using analysis of variance. Behavioral data for the larger study sample were averaged between the 2 testing sessions and summarized using factor analysis. Rotated factor scores were used as dependent variables in multiple regression analyses to test for relationships between behavior and age, rearing condition, and rh5\u2010HTTLPR genotype.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> During the ethanol\u2010testing session, behaviors indicative of motor impairment (stumbles, falls, sways, bumping the wall, and unsuccessful jumps) were frequently observed in the saline\/ethanol group, while they did not occur under the saline\u2010testing session. Factor analysis of behavior following ethanol administration in the larger study sample yielded 3 factors: Ataxia, Impaired Jumping Ability, and Stimulation. Significant negative correlations between age and Ataxia were found for both males and females. Females also exhibited positive correlations between age and Impaired Jumping Ability and age and Stimulation. No significant correlations were found with either rearing condition or rh5\u2010HTTLPR genotype.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> These findings suggest that ontogenetic changes during adolescence in the behavioral response to ethanol differ between rodents and primates. Furthermore, sex differences in the behavioral response to ethanol appear to develop during adolescence.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2006.00300.x","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T10:14:49Z","timestamp":1168424089000},"page":"228-237","source":"Crossref","is-referenced-by-count":13,"title":["Age\u2010Dependent Variation in Behavior Following Acute Ethanol Administration in Male and Female Adolescent Rhesus Macaques (<i>Macaca mulatta<\/i>)"],"prefix":"10.1111","volume":"31","author":[{"given":"Melanie L.","family":"Schwandt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina S.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Suomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Higley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03932.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02242.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ab.10071"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000067976.62827.ED"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000130973.94350.8C"},{"key":"e_1_2_6_7_1","article-title":"Association of a functional polymorphism in the mu\u2010opioid receptor gene (OPRM1C77G) with alcohol response and consumption in male rhesus macaques","author":"Barr CS","journal-title":"Arch Gen Psychiatry"},{"key":"e_1_2_6_8_1","first-page":"221","article-title":"The use of adolescent nonhuman primates to model human alcohol intake","volume":"1021","author":"Barr CS","year":"2004","journal-title":"neurobiological, genetic, and psychological variables"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2004.00065.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb05650.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.116.2.305"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00005.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00100-7"},{"key":"e_1_2_6_14_1","first-page":"201","article-title":"Strain differences in three measures of ethanol intoxication in mice","volume":"2","author":"Crabbe JC","year":"2003","journal-title":"the screen, dowel, and grip strength tests"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevNeurobiol.v15.i1.20"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(03)00134-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00621-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/34.6.894"},{"key":"e_1_2_6_19_1","first-page":"310","article-title":"An animal model for low\u2010dose ethanol\u2010induced locomotor stimulation","volume":"9","author":"Erickson CK","year":"1985","journal-title":"behavioral characteristics"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000113420.28472.25"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050685"},{"key":"e_1_2_6_22_1","first-page":"17","volume-title":"Primate Psychology","author":"Higley JD","year":"2003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01665.x"},{"key":"e_1_2_6_24_1","unstructured":"HollstedtC OlssonO RydbergU(1980)Effects of ethanol on the developing rat. II. Coordination as measured by the tilting\u2010plane test. Med Biol58:164\u2013168."},{"key":"e_1_2_6_25_1","first-page":"219","article-title":"Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol","volume":"239","author":"Imperato A","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_26_1","first-page":"171","article-title":"Age\u2010related differences in the effects of ethanol on performance and behaviour in healthy men","volume":"29","author":"Jones AW","year":"1994","journal-title":"Alcohol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00100.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1972.tb03613.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01945.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000108390.62394.71"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01133.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(00)00054-1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00044.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03668.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(87)80009-X"},{"key":"e_1_2_6_36_1","first-page":"360","article-title":"Observer\u2010rated ataxia","volume":"97","author":"Metten P","year":"2004","journal-title":"rating scales for assessment of genetic differences in ethanol-induced intoxication in mice"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565649809540711"},{"key":"e_1_2_6_38_1","first-page":"207","article-title":"Adolescence","volume":"29","author":"Monti PM","year":"2005","journal-title":"booze, brains, and behavior"},{"key":"e_1_2_6_39_1","first-page":"537","article-title":"Ethanol\u2010induced stimulation and depression on measures of locomotor activity","volume":"10","author":"Moore TO","year":"1993","journal-title":"effects of basal activity levels in rats"},{"key":"e_1_2_6_40_1","first-page":"1485","article-title":"Sensitivity to ethanol across development in rats","volume":"22","author":"Moy SS","year":"1998","journal-title":"comparison to [3H]Zolpidem binding"},{"key":"e_1_2_6_41_1","first-page":"593","article-title":"Place conditioning","volume":"27","author":"Philpot RM","year":"2003","journal-title":"age-related changes in the rewarding and aversive effects of alcohol"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(99)00021-X"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.060"},{"key":"e_1_2_6_44_1","first-page":"445","article-title":"Adolescent ethanol sensitivity","volume":"1021","author":"Ristuccia RC","year":"2004","journal-title":"hypothermia and acute tolerance"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00376-5"},{"key":"e_1_2_6_46_1","first-page":"35","article-title":"Periadolescent rats are less susceptible to ethanol\u2010induced motor impairment than preweanling or young adult rats","volume":"35","author":"Saiers JA","year":"1989","journal-title":"Abstr Int Soc Dev Psychobiol"},{"key":"e_1_2_6_47_1","unstructured":"SchwandtML BarrCS SuomiSJ HigleyJD.Ontogeny of the HPA\u2010axis and monoamine response to acute ethanol challenge in male and female adolescent rhesus macaques. In preparation."},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2345(1998)46:4<311::AID-AJP3>3.0.CO;2-L"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1658"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb04310.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04275.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(99)00055-5"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02560.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2003.12.004"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00014-2"},{"key":"e_1_2_6_56_1","first-page":"71","article-title":"The adolescent brain and the college drinker","volume":"14","author":"Spear LP","year":"2002","journal-title":"biological basis of propensity to use and misuse alcohol"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(97)00135-3"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01011.x"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01509.x"},{"key":"e_1_2_6_60_1","first-page":"163","article-title":"Gender differences in alcohol metabolism","volume":"12","author":"Thomasson HR","year":"1995","journal-title":"physiological responses to ethanol"},{"key":"e_1_2_6_61_1","first-page":"1502","article-title":"Acute effects of ethanol on social behavior of adolescent and adult rats","volume":"26","author":"Varlinskaya EI","year":"2002","journal-title":"role of familiarity of the test situation"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000108655.51087.DF"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.064"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02593.x"},{"key":"e_1_2_6_65_1","first-page":"80","article-title":"Ontogeny of locomotion in rhesus macaques (Macaca mulatta)","volume":"115","author":"Wells JP","year":"2001","journal-title":"II. Postural and locomotor behavior and habitat use in a free-ranging colony"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02628.x"},{"key":"e_1_2_6_67_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.15288\/jsas.1993.s11.62","article-title":"A longitudinal investigation of alcohol use and aggression in adolescence","volume":"11","author":"White HR","year":"1993","journal-title":"J Stud Alcohol"},{"key":"e_1_2_6_68_1","first-page":"206","article-title":"Hippocampal function during adolescence","volume":"1021","author":"White AM","year":"2004","journal-title":"a unique target of ethanol effects"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)00860-2"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(90)90021-4"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1530-0277.2006.00300.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1530-0277.2006.00300.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:49:36Z","timestamp":1697453376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1530-0277.2006.00300.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,10]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1530-0277.2006.00300.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1530-0277.2006.00300.x","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,10]]}}}