{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:27:39Z","timestamp":1792801659909,"version":"4.5.0"},"reference-count":105,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T00:00:00Z","timestamp":1195516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Alcohol consumption induces a dose\u2010dependent noxious effect on skeletal muscle, leading to progressive functional and structural damage of myocytes, with concomitant reductions in lean body mass. Nearly half of high\u2010dose chronic alcohol consumers develop alcoholic skeletal myopathy. The pathogenic mechanisms that lie between alcohol intake and loss of muscle tissue involve multiple pathways, making the elucidation of the disease somewhat difficult.<\/jats:p><jats:p>This review discusses the recent advances in basic and clinical research on the molecular and cellular events involved in the development of alcohol\u2010induced muscle disease. The main areas of recent research interest on this field are as follows: (i) molecular mechanisms in alcohol exposed muscle in the rat model; (ii) gene expression changes in alcohol exposed muscle; (iii) the role of trace elements and oxidative stress in alcoholic myopathy; and (iv) the role of apoptosis and preapoptotic pathways in alcoholic myopathy. These aforementioned areas are crucial in understanding the pathogenesis of this disease. For example, there is overwhelming evidence that both chronic alcohol ingestion and acute alcohol intoxication impair the rate of protein synthesis of myofibrillar proteins, in particular, under both postabsorptive and postprandial conditions. Perturbations in gene expression are contributory factors to the development of alcoholic myopathy, as ethanol\u2010induced alterations are detected in over 400 genes and the protein profile (i.e., the proteome) of muscle is also affected.There is supportive evidence that oxidative damage is involved in the pathogenesis of alcoholic myopathy. Increased lipid peroxidation is related to muscle fibre atrophy, and reduced serum levels of some antioxidants may be related to loss of muscle mass and muscle strength. Finally, ethanol induces skeletal muscle apoptosis and increases both pro\u2010 and antiapoptotic regulatory mechanisms.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2007.00530.x","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T07:12:08Z","timestamp":1195629128000},"page":"1953-1962","source":"Crossref","is-referenced-by-count":90,"title":["Molecular and Cellular Events in Alcohol\u2010Induced Muscle Disease"],"prefix":"10.1111","volume":"31","author":[{"given":"Joaquim","family":"Fernandez\u2010Sol\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor R.","family":"Preedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Gonzalez\u2010Reimers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Arno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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