{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:30:11Z","timestamp":1764700211853},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T00:00:00Z","timestamp":1195516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Individuals with social anxiety disorder and co\u2010occurring alcohol problems report using alcohol to cope with anxiety symptoms. Interventions that reduce both social anxiety and drinking are needed. Paroxetine, an FDA\u2010approved medication to treat social anxiety disorder, reduces anxiety in individuals with co\u2010occurring alcohol problems.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To examine whether effective treatment of social anxiety with paroxetine reduces drinking in dual\u2010diagnosed individuals who endorse using alcohol to cope.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A 16\u2010week, double\u2010blind, randomized controlled trial of paroxetine was conducted. Participants (placebo <jats:italic>n<\/jats:italic>\u2003=\u200322; paroxetine <jats:italic>n<\/jats:italic>\u2003=\u200320) met DSM\u2010IV diagnostic criteria for social anxiety disorder and alcohol abuse or dependence. Participants were seeking treatment for social anxiety, not for the alcohol problem. Alcohol use outcomes were measured with conventional quantity\/frequency measures and novel measures of drinking to cope.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Paroxetine improved social anxiety more than placebo. Paroxetine reduced self\u2010reported reliance on alcohol for self\u2010medication purposes, but was not different than placebo in changing quantity and frequency drinking or the proportion of drinking days that were identified as coping\u2010related. Exploratory analyses revealed that for the placebo group, drinking during the trial was correlated with social anxiety severity, whereas for the paroxetine\u2010treated group, drinking was uncoupled from social anxiety severity.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Successfully treating social anxiety symptoms with paroxetine does not reduce drinking in dual\u2010diagnosed individuals who are not seeking treatment for alcohol problems. Paroxetine does, however, reduce reliance on alcohol to engage in social situations, and may change the reasons why one drinks (such that drinking occurs for other reasons besides coping with anxiety). These results have implications for staging of social anxiety and alcohol treatment in individuals with the co\u2010occurring disorders presenting to a mental health or primary care provider.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2007.00546.x","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T11:15:31Z","timestamp":1195643731000},"page":"77-84","source":"Crossref","is-referenced-by-count":54,"title":["A Complex Relationship Between Co\u2010occurring Social Anxiety and Alcohol Use Disorders: What Effect Does Treating Social Anxiety Have on Drinking?"],"prefix":"10.1111","volume":"32","author":[{"given":"Suzanne E.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick K.","family":"Randall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah 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