{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:30:49Z","timestamp":1793086249072,"version":"4.5.0"},"reference-count":72,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T00:00:00Z","timestamp":1298592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Alcohol exposure in the rat on postnatal days (PD) 4 to 9 is known to partially damage the hippocampus and to impair hippocampus\u2010dependent behavioral tasks. We previously reported that PD4 to 9 alcohol exposure eliminated the context preexposure facilitation effect (CPFE) in juvenile rats, a hippocampus\u2010dependent variant of contextual fear conditioning. In the CPFE, context exposure and immediate shock occur on successive occasions and this produces conditioned freezing relative to a control group that is not preexposed to the training context. Here, we extend our earlier findings by examining the effects of neonatal alcohol administered at multiple doses or over different neonatal exposure periods.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Rat pups (male and female) were exposed to a single binge dose of alcohol at one of 3 doses (2.75, 4.00, or 5.25\u2003g\/kg\/d) over PD4 to 9 (Experiment 1) or to 5.25\u2003g over PD4 to 6 or PD7 to 9 (Experiment 2). Sham\u2010intubated (SI) and undisturbed (UD) rats served as controls. On PD31, rats were preexposed to either the training context (Pre) or an alternate context (No\u2010Pre). On PD32, rats received an immediate unsignaled footshock (1.5\u2003mA, 2\u2003seconds) in the training context. Finally, on PD33, all rats were returned to the training context and tested for contextual freezing over a 5\u2010minute period.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Undisturbed\u2010 and SI\u2010Pre rats showed the CPFE, i.e., context preexposure facilitated contextual conditioning, relative to their No\u2010Pre counterparts. The immediate shock deficit was present in all No\u2010Pre groups, regardless of previous alcohol exposure. In Experiment 1, blood alcohol level was negatively correlated with contextual freezing. Group 2.75\u2003g\u2010Pre did not differ from controls. Group 4.00\u2003g\u2010Pre froze significantly less than Groups UD\u2010 and SI\u2010Pre but more than Group 5.25\u2010Pre, which showed the immediate shock deficit. In Experiment 2, alcohol exposure limited to PD7 to 9, but not PD4 to 6, disrupted the CPFE.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This is the first demonstration of dose\u2010related impairment on a hippocampus\u2010dependent task produced by neonatal alcohol exposure in the rat. Exposure period effects support previous studies of alcohol and spatial learning. The CPFE is a more sensitive behavioral task that can be used to elucidate developmental alcohol\u2010induced deficits over a range of alcohol doses that are more relevant to human exposure levels.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2011.01449.x","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T16:03:45Z","timestamp":1298736225000},"page":"1160-1170","source":"Crossref","is-referenced-by-count":29,"title":["Effects of Dose and Period of Neonatal Alcohol Exposure on the Context Preexposure Facilitation Effect"],"prefix":"10.1111","volume":"35","author":[{"given":"Nathen J.","family":"Murawski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark 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