{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:52:16Z","timestamp":1779101536628,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Concurrent inhibitors of dopamine, norepinephrine, and serotonin uptake have been proposed as novel antidepressants. Given the high comorbidity between alcoholism and depression, we evaluated the activity of DOV 102,677 (DOV) on alcohol\u2010maintained responding and performance in the forced swim test (FST), a model of antidepressant (AD) activity, using alcohol\u2010preferring (P) rats.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Following training to lever press for either alcohol (10% v\/v) or sucrose (3, 2%, w\/v) on a fixed\u2010ratio 4 (FR4) schedule, DOV (1.56 to 50\u2003mg\/kg; PO) was given 25\u2003minutes or 24\u2003hours prior to evaluation. The effects of DOV (12.5 to 50\u2003mg\/kg; PO) in the FST were evaluated 25\u2003minutes posttreatment.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> DOV (6.25 to 50\u2003mg\/kg) dose\u2010dependently reduced alcohol\u2010maintained responding by 59 to 88% at 25\u2003minutes posttreatment, without significantly altering sucrose responding. The reduction in alcohol responding (44% at 50\u2003mg\/kg) was sustained for up to 120\u2003hours after a single dose. Administration of a single dose of DOV (25, 50\u2003mg\/kg) 24\u2003hours before testing suppressed alcohol responding for 48\u2003hours by 59 to 62%. DOV (12.5 to 50\u2003mg\/kg) also dose\u2010dependently reduced immobility of P rats in the FST.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> DOV produces both prolonged and selective reductions of alcohol\u2010motivated behaviors in P rats. The elimination kinetics of DOV suggests that its long duration of action may be due to an active metabolite. DOV also produced robust AD\u2010like effects in P rats. We propose that DOV may be useful in treating comorbid alcoholism and depression in humans.<\/jats:p>","DOI":"10.1111\/j.1530-0277.2011.01671.x","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T18:25:37Z","timestamp":1323282337000},"page":"863-873","source":"Crossref","is-referenced-by-count":9,"title":["Effects of the Triple Monoamine Uptake Inhibitor DOV 102,677 on Alcohol\u2010Motivated Responding and Antidepressant Activity in Alcohol\u2010Preferring (P) Rats"],"prefix":"10.1111","volume":"36","author":[{"given":"Andrew R. S. T.","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heon S.","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlin T.","family":"Warnock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Mamczarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Harry L.","family":"June","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Krieter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Tonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Skolnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony S.","family":"Basile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Sr.","given":"Harry L.","family":"June","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,7]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"American Psychiatric Association(2000)Diagnostic and Statistical Manual of Mental Disorders.4th ed. 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