{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:56:39Z","timestamp":1792716999489,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T00:00:00Z","timestamp":1328832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T00:00:00Z","timestamp":1328832000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp; Exp Res"],"published-print":{"date-parts":[[2012,7]]},"abstract":"\n Background<\/jats:title>\n \n Binge\u2010like alcohol exposure in neonatal rats during the brain growth spurt causes deficits in adult neurogenesis in the hippocampal dentate gyrus (\n DG<\/jats:styled-content>\n ). Previous data from our laboratory demonstrated that 12 days of voluntary wheel running (\n WR<\/jats:styled-content>\n ) beginning on postnatal day (\n PD<\/jats:styled-content>\n ) 30 significantly increased the number of newly generated cells evident in the\n DG<\/jats:styled-content>\n on\n PD<\/jats:styled-content>\n 42 in both alcohol\u2010exposed (\n AE<\/jats:styled-content>\n ) and control rats, but 30\u00a0days later a sustained beneficial effect of\n WR<\/jats:styled-content>\n was evident only in control rats. This study tested the hypothesis that housing rats in environmental complexity (\n EC<\/jats:styled-content>\n ) following\n WR<\/jats:styled-content>\n would promote the survival of the newly generated cells stimulated by\n WR<\/jats:styled-content>\n , particularly in\n AE<\/jats:styled-content>\n rats.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n On\n PD<\/jats:styled-content>\n 4 to 9, pups were intubated with alcohol in a binge\u2010like manner (5.25\u00a0g\/kg\/d), sham\u2010intubated (\n SI<\/jats:styled-content>\n ), or reared normally. In Experiment 1, animals were either assigned to\n WR<\/jats:styled-content>\n during\n PD<\/jats:styled-content>\n 30 to 42 or socially housed (\n SH<\/jats:styled-content>\n ). On\n PD<\/jats:styled-content>\n 42, animals were injected with bromodeoxyuridine (\n BrdU<\/jats:styled-content>\n ; 200\u00a0mg\/kg) and perfused 2\u00a0hours later to confirm the\n WR<\/jats:styled-content>\n \u2010induced stimulation of proliferation. In\n E<\/jats:styled-content>\n xperiment 2, all animals received\n WR<\/jats:styled-content>\n on\n PD<\/jats:styled-content>\n 30 to 42 and were injected with\n BrdU<\/jats:styled-content>\n on the last full day of\n WR<\/jats:styled-content>\n . On\n PD<\/jats:styled-content>\n 42, animals were randomly assigned either to\n EC<\/jats:styled-content>\n (\n WR<\/jats:styled-content>\n \/\n EC<\/jats:styled-content>\n ) or to\n SH<\/jats:styled-content>\n (\n WR<\/jats:styled-content>\n \/\n SH<\/jats:styled-content>\n ) for 30\u00a0days and subsequently perfused and brains were processed for immunohistochemical staining to identify\n BrdU<\/jats:styled-content>\n +\u2010,\n Ki<\/jats:styled-content>\n 67+\u2010, and\n BrdU<\/jats:styled-content>\n +\/\n NeuN<\/jats:styled-content>\n +\u2010labeled cells in\n DG<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In Experiment 1,\n WR<\/jats:styled-content>\n exposure significantly increased the number of proliferating cells in all 3 postnatal conditions. In Experiment 2, the\n AE<\/jats:styled-content>\n rats given\n WR<\/jats:styled-content>\n \/\n SH<\/jats:styled-content>\n had significantly fewer\n BrdU<\/jats:styled-content>\n + cells compared with control rats given\n WR<\/jats:styled-content>\n \/\n SH<\/jats:styled-content>\n . However,\n WR<\/jats:styled-content>\n \/\n EC<\/jats:styled-content>\n experience significantly increased the number of surviving\n BrdU<\/jats:styled-content>\n + cells in both the\n AE<\/jats:styled-content>\n and\n SI<\/jats:styled-content>\n groups compared with\n WR<\/jats:styled-content>\n \/\n SH<\/jats:styled-content>\n rats of the same neonatal treatment. Approximately 80% of the surviving\n BrdU<\/jats:styled-content>\n + cells in the\n DG<\/jats:styled-content>\n across the conditions were colabeled with\n NeuN<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n WR<\/jats:styled-content>\n followed by\n EC<\/jats:styled-content>\n could provide a behavioral model for developing interventions in humans to ameliorate hippocampal\u2010dependent impairments associated with fetal alcohol spectrum disorders.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1530-0277.2011.01726.x","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T21:02:27Z","timestamp":1328907747000},"page":"1196-1204","source":"Crossref","is-referenced-by-count":38,"title":["Housing in Environmental Complexity Following Wheel Running Augments Survival of Newly Generated Hippocampal Neurons in a Rat Model of Binge Alcohol Exposure During the Third Trimester 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