{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:33:00Z","timestamp":1790775180420,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Measurement of liver stiffness (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>) using real\u2010time elastography appears as a promising tool to evaluate the severity of chronic liver diseases. Previous studies in patients with alcoholic liver disease have suggested that fibrosis was the only histological parameter to influence <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>. To challenge this hypothesis, we have prospectively tested the short\u2010term impact of alcohol withdrawal on <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Patients hospitalized for alcohol withdrawal in our <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ddiction <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nit between 2007 and 2010 had an <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> determination at entry (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>0) and 7\u00a0days after alcohol withdrawal (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>7). <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> value was given as the median of 10 measurements performed with a <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ibroScan<jats:sup>\u00ae<\/jats:sup> device. For a given patient, variation of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> was considered as significant when the comparison of the 10 measurements at <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>0 and at <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>7 yielded a <jats:italic>p<\/jats:italic>\u2010value under 0.05 (<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ilcoxon test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>One hundred and thirty\u2010seven patients were included in the study (median alcohol consumption: 150\u00a0g\/d; hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>:<jats:italic> n<\/jats:italic>\u00a0=\u00a021 [15.6%]). Considering all patients, median <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> value decreased from 7.2 to 6.1\u00a0<jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a between <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>0 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>7 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.00001, paired <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>ilcoxon test). <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> decreased significantly in 62 patients (45.3%), and there was a reduction in the estimated stage of fibrosis in 32 (23.3%). <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> increased significantly in 16 patients (11.7%). Subgroup analyses revealed that the decrease in <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> was still significant in patients with or without hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> infection, and aspartate transaminase level below or above 100\u00a0<jats:styled-content style=\"fixed-case\">UI<\/jats:styled-content>\/l.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> decreases significantly in nearly half of heavy drinkers after only 7\u00a0days of abstinence. This result strongly suggests that nonfibrotic lesions (such as the presence of alcoholic hepatitis) may influence <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>. From a practical point of view, it also shows that variation of alcohol consumption must be taken into account for the interpretation of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1530-0277.2012.01737.x","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T21:22:30Z","timestamp":1331241750000},"page":"1407-1411","source":"Crossref","is-referenced-by-count":90,"title":["Rapid Decline of Liver Stiffness Following Alcohol Withdrawal in Heavy Drinkers"],"prefix":"10.1111","volume":"36","author":[{"given":"Jean\u2010Baptiste","family":"Trabut","sequence":"first","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Th\u00e9pot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Nalpas","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"},{"name":"U\u20101016 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Lavielle","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Cosconea","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"},{"name":"Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Corouge","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"},{"name":"Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Vallet\u2010Pichard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"},{"name":"U\u20101016 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Mallet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; H\u00f4pital Cochin, Assitance Publique \u2010 H\u00f4pitaux de Paris Paris France"},{"name":"Universit\u00e9 Paris Descartes Paris France"},{"name":"U\u20101016 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Sogni","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9patologie et d'Addictologie ;][#,63]?&gt; 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