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In the peri\u2010adolescent exposure group, ethanol significantly reduced body weight gain to a similar extent in both male and female mice (82 and 84% of controls, respectively). In adult animals, body weight gain was much less than that of the peri\u2010adolescent mice, with ethanol having a small but significant effect in males but not females. Between the control peri\u2010adolescent and adult cohorts (measurements taken at <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>70 and 225, respectively), there were no significant differences in the mass of the cerebral cortex or the cerebellum from either male or female mice, although the rostro\u2010caudal length of the corpus callosum increased slightly but significantly (6.1%) between these time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ethanol treatment significantly reduced the mass of the cerebral cortex in peri\u2010adolescent (\u22123.1%), but not adult, treated mice. By contrast, ethanol significantly reduced the length of the corpus callosum in adult (\u22125.4%), but not peri\u2010adolescent, treated mice. 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