{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:16:01Z","timestamp":1790118961260,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Heavy drinkers show altered functional magnetic resonance imaging (f<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) response to alcohol cues. Little is known about alcohol cue reactivity among college age drinkers, who show the greatest rates of alcohol use disorders. Family history of alcoholism (family history positive [<jats:styled-content style=\"fixed-case\">FHP<\/jats:styled-content>]) is a risk factor for problematic drinking, but the impact on alcohol cue reactivity is unclear. We investigated the influence of heavy drinking and family history of alcoholism on alcohol cue\u2010related f<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> response among college students.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were 19 family history negative (<jats:styled-content style=\"fixed-case\">FHN<\/jats:styled-content>) light drinkers, 11 <jats:styled-content style=\"fixed-case\">FHP<\/jats:styled-content> light drinkers, 25 <jats:styled-content style=\"fixed-case\">FHN<\/jats:styled-content> heavy drinkers, and 10 <jats:styled-content style=\"fixed-case\">FHP<\/jats:styled-content> heavy drinkers, aged 18 to 21. During f<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scanning, participants viewed alcohol images, nonalcohol beverage images, and degraded control images, with each beverage image presented twice. We characterized blood oxygen level\u2010dependent (<jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content>) contrast for alcohol versus nonalcohol images and examined <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> response to repeated alcohol images to understand exposure effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Heavy drinkers exhibited greater <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> response than light drinkers in posterior visual association regions, anterior cingulate, medial frontal cortex, hippocampus, amygdala, and dorsal striatum, and hyperactivation to repeated alcohol images in temporo\u2010parietal, frontal, and insular regions (clusters\u00a0&gt;\u00a08,127\u00a0\u03bcl, <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). <jats:styled-content style=\"fixed-case\">FHP<\/jats:styled-content> individuals showed increased activation to repeated alcohol images in temporo\u2010parietal regions, fusiform, and hippocampus. There were no interactions between family history and drinking group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results parallel findings of hyperactivation to alcohol cues among heavy drinkers in regions subserving visual attention, memory, motivation, and habit. Heavy drinkers demonstrated heightened activation to repeated alcohol images, which could influence continued drinking. Family history of alcoholism was associated with greater response to repeated alcohol images in regions underlying visual attention, recognition, and encoding, which could suggest aspects of alcohol cue reactivity that are independent of personal drinking. Heavy drinking and family history of alcoholism may have differential impacts on neural circuitry involved in cue reactivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1530-0277.2012.01879.x","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T00:27:42Z","timestamp":1350606462000},"source":"Crossref","is-referenced-by-count":58,"title":["Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers"],"prefix":"10.1111","volume":"37","author":[{"given":"Alecia D.","family":"Dager","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale University New Haven Connecticut"},{"name":"Olin Neuropsychiatry Research Center Hartford Hospital Hartford Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Olin Neuropsychiatry Research Center Hartford Hospital Hartford 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