{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:42:25Z","timestamp":1768261345216,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":12414,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p>\n                    <jats:bold>ABSTRACT:<\/jats:bold>\n                    This study involved 27 geriatric patients with asymptomatic chronic bacteriuria; all had indwelling Foley catheters. The treatment regimens (daily oral dosage) were: methenamine mandelate (MM) granules, 4 gm; MM, 4 gm, plus ascorbic acid, 4 gm; and MM, 4 gm, plus ascorbic acid, 4 gm, plus cranberry cocktail, 1 liter\u2014administered according to a cross\u2010over design. Proteus vulgaris, Pseudomonas aeruginosa and E. coli were the most common urinary organisms. Proteus organisms were more often found in alkaline than in acidic urines, but the type of pathogen had no influence on urinary pH. Urinary formaldehyde concentration [HCHO] was lower in patients with Proteus infection (17.7 \u03bcg\/ml) than in those with Pseudomonas (21.9 \u03bcg\/ml) or E. coli infection (21.8 \u03bcg\/ml). However, for Proteus infection, [HCHO] was higher in patients receiving MM plus ascorbic acid than in those receiving MM alone. Addition of cranberry cocktail to ascorbic acid did not enhance urinary pH, [HCHO] or methenamine efficacy. Our data suggest that in Foley catheter patients with chronic asymptomatic bacteriuria secondary to Proteus, Pseudomonas or E. coli infection, the type of urinary pathogen or the urinary pH cannot be used to predict the efficacy of methenamine therapy either with or without urinary acidifying agents.\n                  <\/jats:p>","DOI":"10.1111\/j.1532-5415.1981.tb01774.x","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T10:39:52Z","timestamp":1430303992000},"page":"236-239","source":"Crossref","is-referenced-by-count":13,"title":["Predictability of Methenamine Efficacy Based on Type of Urinary Pathogen and pH"],"prefix":"10.1111","volume":"29","author":[{"given":"MILAP C.","family":"NAHATA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRITT A.","family":"CUMMINS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DON C.","family":"McLEOD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RICHARD","family":"BUTLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0022-5347(17)69964-6","article-title":"The treatment of urinary infections with mandelamine (methenamine mandelate); a clinical study of 200 cases","volume":"55","author":"Carroll G","year":"1946","journal-title":"J Urol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-69-4-655"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0022-5347(17)62622-3","article-title":"The prolonged use of methenamine hippurate in the treatment of chronic urinary tract infections","volume":"100","author":"Gerstein AR","year":"1968","journal-title":"J Urol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197409192911203"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0022-5347(17)69091-8","article-title":"Some antibacterial properties of mandelamine (methenamine mandelate)","volume":"61","author":"Scudi JV","year":"1949","journal-title":"J Urol"},{"key":"e_1_2_5_7_2","first-page":"615","article-title":"Methenamine mandelate: antimicrobial activity, absorption and excretion","volume":"2","author":"Knight V","year":"1952","journal-title":"Antibiot Chemother"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.6.6.708"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195910152611608"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)80223-2"},{"key":"e_1_2_5_11_2","first-page":"560","article-title":"Prevention of recurrent urinary tract infections in girls","volume":"105","author":"Holland NH","year":"1963","journal-title":"Am J Dis Child"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0022-5347(17)63619-X","article-title":"Ascorbic acid as a urinary acidifying agent. 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Its adjunctive role in chronic urinary infections","volume":"94","author":"Murphy FJ","year":"1965","journal-title":"J Urol"},{"key":"e_1_2_5_14_2","first-page":"1234","article-title":"Effect of ascorbic acid on urine pH in man","volume":"34","author":"Nahata MC","year":"1977","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_5_15_2","first-page":"282","article-title":"Observations on the effectiveness of cranberry juice in urinary infections","volume":"61","author":"Moen DV","year":"1962","journal-title":"Wisconsin Med J"},{"key":"e_1_2_5_16_2","first-page":"17","article-title":"Cranberry juice in the treatment of urinary tract infections","volume":"47","author":"Papas PN","year":"1966","journal-title":"Southwest Med"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0021-9258(18)85489-8","article-title":"Studies of urinary acidity: the increased acidity produced by eating prunes and cranberries","volume":"57","author":"Blatherwick NR","year":"1923","journal-title":"J Biol Chem"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/jn\/6.5.455","article-title":"Effect of cranberries on urinary acidity and blood alkali reserve","volume":"6","author":"Fellers CR","year":"1933","journal-title":"J Nutr"},{"key":"e_1_2_5_19_2","first-page":"881","article-title":"Cranberry juice and the antibacterial action of hippuric acid","volume":"54","author":"Bodel PT","year":"1959","journal-title":"J Lab Clin Med"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0002-8223(21)11836-X","article-title":"Effect of cranberry juice on urine","volume":"51","author":"Kahn HD","year":"1967","journal-title":"J Am Diet Assoc"},{"key":"e_1_2_5_21_2","first-page":"556","article-title":"Urine pH; effect of prescribed regimes of cranberry juice and ascorbic acid (Abstract)","volume":"56","author":"Nickey KE","year":"1975","journal-title":"Arch Phys Med Rehab"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.12.5.625"},{"key":"e_1_2_5_23_2","first-page":"212","article-title":"Selective determination of free urinary formaldehyde after oral dosage with methenamine mandelate","volume":"10","author":"Chen TM","year":"1972","journal-title":"Invest Urol"},{"key":"e_1_2_5_24_2","first-page":"91","article-title":"The antimicrobial activity of urine of paraplegic patients receiving methenamine mandelate","volume":"16","author":"Pearman JW","year":"1978","journal-title":"Invest Urol"},{"key":"e_1_2_5_25_2","first-page":"1013","article-title":"Infections of the Urinary Tract. 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