{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:15:12Z","timestamp":1777616112570,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T00:00:00Z","timestamp":1148256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>\n                    <jats:bold>OBJECTIVES:<\/jats:bold>\n                    To determine whether patients undergoing carotid endarterectomy (CE) for symptomatic left internal carotid artery (LICA) stenosis have greater risk of cognitive decline than patients with asymptomatic LICA disease or right internal carotid artery (RICA) disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DESIGN:<\/jats:bold>\n                    Observational.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>SETTING:<\/jats:bold>\n                    Vascular surgery day hospital.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>PARTICIPANTS:<\/jats:bold>\n                    The analysis included 103 patients (mean age 72.6\u00b17.0, 73 men), of whom 50 had LICA disease (29 symptomatic).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>MEASUREMENTS:<\/jats:bold>\n                    Cognitive function was evaluated (age\u2010 and education\u2010adjusted Mini\u2010Mental State Examination (MMSE), and Clock tests (CLOX1 and 2)) at baseline and at the end of the study period (average follow\u2010up\u00b1standard deviation 44.4\u00b114.3 months) in a sample of patients aged 65 and older, free from cognitive impairment, consecutively undergoing CE.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    At the end of the study period, MMSE, CLOX1, and CLOX2 scores were significantly lower in patients with symptomatic LICA disease (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.001,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.001, and\n                    <jats:italic>P<\/jats:italic>\n                    =.002, respectively) and not in the other groups of patients. Patients with symptomatic LICA disease had greater risk of cognitive decline than other individuals according to MMSE score (\n                    <jats:italic>F<\/jats:italic>\n                    =5.18,\n                    <jats:italic>P<\/jats:italic>\n                    =.002) or CLOX1 and 2 scores (\n                    <jats:italic>F<\/jats:italic>\n                    =5.66,\n                    <jats:italic>P<\/jats:italic>\n                    =.001, and\n                    <jats:italic>F<\/jats:italic>\n                    =4.33,\n                    <jats:italic>P<\/jats:italic>\n                    =.006, respectively).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    Patients undergoing CE for symptomatic LICA disease appear to be at greater risk of cognitive decline than other subjects. These findings suggest that future studies should evaluate the effects on cognitive function of different timing for CE in patients with LICA and RICA disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1532-5415.2006.00787.x","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T11:18:15Z","timestamp":1148296695000},"page":"932-936","source":"Crossref","is-referenced-by-count":41,"title":["Risk of Cognitive Decline in Older Patients After Carotid Endarterectomy: An Observational Study"],"prefix":"10.1111","volume":"54","author":[{"given":"Mario","family":"Bo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Massaia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Speme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgetta","family":"Cappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khenya","family":"Strumia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Cerrato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Ponzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leone","family":"Poli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12228-3"},{"key":"e_1_2_7_3_2","first-page":"669","article-title":"Cognitive disorders in patients with occlusive disease of the carotid artery","volume":"247","author":"Bakker FC","year":"2000","journal-title":"A systematic review of the literature"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000054050.51530.76"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11667-9"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340047031"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000028235.91778.95"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-4-200402170-00005"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1996.tb01851.x"},{"key":"e_1_2_7_11_2","volume-title":"Cerebrovascular Disorders: A Clinical and Research Classification","year":"1978"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14544-8"},{"key":"e_1_2_7_13_2","first-page":"1625","article-title":"A method for using MR to evaluate the effects of cardiovascular disease on the brain","volume":"15","author":"Bryan RN","year":"1994","journal-title":"The cardiovascular health study"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250701"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.5.588"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540290067019"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.5.496"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1185"},{"key":"e_1_2_7_20_2","first-page":"P328","article-title":"Clock drawing is sensitive to executive control","volume":"54","author":"Royall DR","year":"1999","journal-title":"A comparison of six methods"},{"key":"e_1_2_7_21_2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1994"},{"key":"e_1_2_7_22_2","first-page":"939","article-title":"Clinical diagnosis of Alzheimer's disease","volume":"34","author":"McKahnn G","year":"1984","journal-title":"Reports of the NINCDS-ARDRA Work Group under auspices of department of Health and Human Services Task Force on Alzheimer's disease"},{"key":"e_1_2_7_23_2","first-page":"250","article-title":"Vascular dementia","volume":"43","author":"Roman GC","year":"1993","journal-title":"Diagnostic criteria for research studies. 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