{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:05:46Z","timestamp":1792886746866,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    <jats:bold>OBJECTIVES:<\/jats:bold>\n                    To identify morphological orthostatic blood pressure (BP) phenotypes in older people and assess their correlation with orthostatic intolerance (OI), falls, and frailty and to compare the discriminatory performance of a morphological classification with two established orthostatic hypotension (OH) definitions: consensus (COH) and initial (IOH).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DESIGN:<\/jats:bold>\n                    Cross\u2010sectional.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>SETTING:<\/jats:bold>\n                    Geriatric research clinic.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>PARTICIPANTS:<\/jats:bold>\n                    Four hundred forty\u2010two participants (mean age 72, 72% female) without dementia or risk factors for autonomic neuropathy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>MEASUREMENTS:<\/jats:bold>\n                    Active lying\u2010to\u2010standing test monitored using a continuous noninvasive BP monitor. For the morphological classification, four orthostatic systolic BP variables were extracted (delta (baseline \u2013 nadir) and maximum percentage of baseline recovered by 30 seconds and 1 and 2 minutes) using the 5\u2010second averages method and entered in K\u2010means cluster analysis (three clusters). Main outcomes were OI, falls (\u22651 in past 6 months), and frailty (modified Fried criteria).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    The morphological clusters were small drop, fast overrecovery (n=112); medium drop, slow recovery (n=238); and large drop, nonrecovery (n=92). Their characterization revealed an increasing OI gradient (17.9%, 27.5%, and 44.6% respectively,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.001) but no significant gradients in falls or frailty. The COH definition failed to reveal clinical differences between COH+ (n=416) and COH\u2212 (n=26) participants. The IOH definition resulted in a clinically meaningful separation between IOH+ (n=85) and IOH\u2212 (n=357) subgroups, as assessed according to OI (100% vs 11.5%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.001), falls (24.7% vs 10.4%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.001), and frailty (14.1% vs 5.4%,\n                    <jats:italic>P<\/jats:italic>\n                    =.005).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    It is recommended that the IOH definition be applied when taking continuous noninvasive orthostatic BP measurements in older people.\n                  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