{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:43:14Z","timestamp":1773675794853,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T00:00:00Z","timestamp":1303344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>\n                    <jats:bold>OBJECTIVES:<\/jats:bold>\n                    To assess the additive value of a newly marketed interferon\u2010gamma release assay, QuantiFERON\u2010TB Gold In\u2010Tube (QFT\u2010GIT), to a single tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) in older adults who have been exposed to TB in a nursing home.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DESIGN:<\/jats:bold>\n                    Contact tracing included clinical examination, chest radiography, TST, and QFT\u2010GIT in TST\u2010negative people (TST&lt;5\u2003mm).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>SETTING:<\/jats:bold>\n                    A private nursing home.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>PARTICIPANTS:<\/jats:bold>\n                    Seventy\u2010seven individuals (63 elderly residents, 14 young employees) who had been exposed to an active TB case in a private nursing home.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>MEASUREMENTS:<\/jats:bold>\n                    Comparison of TST and QFT\u2010GIT in older adults who have been exposed to TB.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    For the TST, the positive response rate was 31.7% (n=20) of elderly residents and 43% (n=6) of staff. Positive QFT\u2010GIT results were obtained in seven (16.3%) elderly residents with negative TST, six of whom were aged 80 and older. QFT\u2010GIT increased the percentage of possible LTBI in this group from 31.7% to 42.9%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    QFT\u2010GIT has a significant additive value to single TST for detecting LTBI in institutionalized older adults, identifying infected subjects anergic to the TST.\n                  <\/jats:p>","DOI":"10.1111\/j.1532-5415.2011.03367.x","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T12:07:47Z","timestamp":1303387667000},"page":"858-862","source":"Crossref","is-referenced-by-count":12,"title":["Use of Interferon\u2010Gamma Release Assay for Latent Tuberculosis Infection Screening in Older Adults Exposed to Tuberculosis in a Nursing Home"],"prefix":"10.1111","volume":"59","author":[{"given":"Stamatis","family":"Katsenos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melita","family":"Nikolopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantina","family":"Gartzonika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Manda\u2010Stachouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athena","family":"Gogali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christodoula","family":"Grypaiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anestis","family":"Mavridis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavros H.","family":"Constantopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Daskalopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,21]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"665","article-title":"Revised guidelines for the diagnosis and control of tuberculosis","volume":"22","author":"Van den Brande R.","year":"2005","journal-title":"Impact on management in the elderly"},{"key":"e_1_2_6_3_2","first-page":"S64","article-title":"Tuberculosis among elderly persons, as observed among nursing home residents","volume":"2","author":"Stead WW.","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.supplement_3.ats600"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-3-199702010-00005"},{"key":"e_1_2_6_6_2","first-page":"177","article-title":"Systematic review","volume":"149","author":"Pai M","year":"2008","journal-title":"T-cell-based assays for the diagnosis of latent tuberculosis infection: An update"},{"key":"e_1_2_6_7_2","unstructured":"Cellestis Limited QuantiFERON\u2010TB Gold (in\u2010tube method) [package insert] [on\u2010line]. 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